Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma.
Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma.
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DOI：
10.1371/journal.pone.0010481
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发表时间：
2010-05-05
期刊：
影响因子：
3.7
通讯作者：
Kamitani T
中科院分区：
文献类型：
--
作者：
Matsuo Y;Kamitani T
黑色素瘤是全球皮肤癌死亡的主要原因。帕金森病是一种神经退行性疾病，由α-突触核蛋白或其他基因突变引起。重要的是，流行病学研究报告了黑色素瘤和帕金森病的共同发生，这表明这两种疾病可能具有共同的基因成分。最近，我们发现人黑色素瘤细胞株高表达α-突触核蛋白，而在所测试的非黑色素瘤癌细胞株中未检测到该蛋白。为了研究α-突触核蛋白在人黑色素瘤组织中的表达，我们对黑色素瘤、痣、非黑素细胞皮肤癌和正常皮肤进行了免疫组织化学染色。α突触核蛋白在86%的原发黑色素瘤切片和85%的转移黑色素瘤切片中呈阳性表达，在的痣切片中也呈阳性表达。然而，α-突触核蛋白在非黑素细胞皮肤癌和正常皮肤中检测不到。帕金森氏病相关蛋白α-突触核蛋白在恶性和良性黑素细胞病变中都有表达，如黑色素瘤和色素痣。虽然α-突触核蛋白不能用于区分恶性和良性黑素细胞皮肤病变，但它可能是诊断转移性黑色素瘤的有用生物标记物。
Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of α-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and Parkinson's disease, suggesting that these two diseases could share common genetic components. Recently, we found that human melanoma cell lines highly express α-synuclein, whereas the protein is undetectable in the non-melanoma cancer cell lines tested. To investigate the expression of α-synuclein in human melanoma tissues, we immunostained sections of melanoma, nevus, non-melanocytic cutaneous carcinoma, and normal skin. α-Synuclein was positively detected in 86% of the primary and 85% of the metastatic melanoma sections, as well as in 89% of nevus sections. However, α-synuclein was undetectable in non-melanocytic cutaneous carcinoma and normal skin. The Parkinson's disease-related protein, α-synuclein, is expressed in both malignant and benign melanocytic lesions, such as melanomas and nevi. Although α-synuclein cannot be used to distinguish between malignant and benign melanocytic skin lesions, it might be a useful biomarker for the diagnosis of metastatic melanoma.
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影响因子：
3.5
作者：
Batistatou, Anna;Cook, Martin G.;Massi, Daniela
通讯作者：
Massi, Daniela
影响因子：
3.7
作者：
通讯作者：
--
影响因子：
3.9
作者：
Cormier, JN;Abati, A;Topalian, SL
通讯作者：
Topalian, SL
DOI：
10.1016/j.bbadis.2008.09.013
发表时间：
2009-07
影响因子：
6.2
作者：
Waxman, Elisa A.;Giasson, Benoit I.
通讯作者：
Giasson, Benoit I.
影响因子：
4.5
作者：
De Mazière, AM;Muehlethaler, K;Rimoldi, D
通讯作者：
Rimoldi, D