Using zebrafish to study podocyte genesis during kidney development and regeneration.
Using zebrafish to study podocyte genesis during kidney development and regeneration.
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DOI：
10.1002/dvg.22798
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发表时间：
2014-09
期刊：
影响因子：
1.5
通讯作者：
Wingert, Rebecca A.
中科院分区：
文献类型：
--
作者：
Kroeger, Paul T., Jr.;Wingert, Rebecca A.
在发育过程中，脊椎动物形成了多达三个不同的肾脏，这些肾脏由称为肾元的功能单位组成。肾元的组成在物种间是高度保守的，人们越来越多地认识到斑马鱼和哺乳动物肾元细胞类型之间的相似性，这使得斑马鱼成为肾脏发生研究的相关遗传系统。肾元血液过滤器的关键组成部分是一种称为足细胞的特化上皮细胞。足细胞的研究是至关重要的，因为绝大多数肾脏疾病始于足细胞功能障碍或丧失，导致蛋白尿，导致肾细胞变性，最终导致肾衰竭。了解足细胞在器官发生过程中是如何发育的，可以阐明通过刺激肾脏疾病患者的足细胞替代来促进肾细胞健康的新方法。在这篇综述中，我们讨论了如何使用斑马鱼模型来研究肾脏发育，以及斑马鱼研究如何为足细胞谱系规范和分化提供新的见解。此外，我们讨论了成年斑马鱼足细胞再生的最新发现，并探讨了斑马鱼的持续基础研究如何为胚胎和成年环境下足细胞的发生提供重要的知识。
During development, vertebrates form a progression of up to three different kidneys that are comprised of functional units termed nephrons. Nephron composition is highly conserved across species, and an increasing appreciation of the similarities between zebrafish and mammalian nephron cell types has positioned the zebrafish as a relevant genetic system for nephrogenesis studies. A key component of the nephron blood filter is a specialized epithelial cell known as the podocyte. Podocyte research is of the utmost importance as a vast majority of renal diseases initiate with the dysfunction or loss of podocytes, resulting in a condition known as proteinuria that causes nephron degeneration and eventually leads to kidney failure. Understanding how podocytes develop during organogenesis may elucidate new ways to promote nephron health by stimulating podocyte replacement in kidney disease patients. In this review, we discuss how the zebrafish model can be used to study kidney development, and how zebrafish research has provided new insights into podocyte lineage specification and differentiation. Further, we discuss the recent discovery of podocyte regeneration in adult zebrafish, and explore how continued basic research using zebrafish can provide important knowledge about podocyte genesis in embryonic and adult environments.
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