Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development.
Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development.
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DOI：
10.3389/fgene.2021.652747
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发表时间：
2021
影响因子：
3.7
通讯作者：
Abou-Kheir W
中科院分区：
文献类型：
--
作者：
Bahmad HF;Jalloul M;Azar J;Moubarak MM;Samad TA;Mukherji D;Al-Sayegh M;Abou-Kheir W
前列腺癌（PCa）是迄今为止全球男性中最常见的诊断癌症。尽管对雄激素剥夺敏感，但晚期疾病患者最终对治疗产生耐药性，并可能死于转移性去势抵抗性前列腺癌（mCRPC）。PCa管理的一个关键挑战是难以使用现有生物标志物预测的临床异质性。定义PCa的分子生物标志物，可以可靠地帮助诊断和区分需要积极治疗的患者和应该避免过度治疗的患者，这是一个重大的未满足的需求。PCa的发生机制不仅限于癌上皮细胞，还涉及肿瘤微环境。前列腺癌中上皮细胞和间质之间的相互作用已被证明在疾病进展和转移中起着不可或缺的作用。已经鉴定了反应性基质的许多关键标志物，包括干细胞/祖细胞标志物、基质衍生的炎症介质、血管生成调节因子、结缔组织生长因子、无翼同源物（Wnt）和整联蛋白。在这里，我们提供了一个概要的间质上皮串扰PCa集中在相关的分子生物标志物有关的肿瘤微环境及其在诊断，预后和治疗发展的作用。
Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide. Despite sensitivity to androgen deprivation, patients with advanced disease eventually develop resistance to therapy and may die of metastatic castration-resistant prostate cancer (mCRPC). A key challenge in the management of PCa is the clinical heterogeneity that is hard to predict using existing biomarkers. Defining molecular biomarkers for PCa that can reliably aid in diagnosis and distinguishing patients who require aggressive therapy from those who should avoid overtreatment is a significant unmet need. Mechanisms underlying the development of PCa are not confined to cancer epithelial cells, but also involve the tumor microenvironment. The crosstalk between epithelial cells and stroma in PCa has been shown to play an integral role in disease progression and metastasis. A number of key markers of reactive stroma has been identified including stem/progenitor cell markers, stromal-derived mediators of inflammation, regulators of angiogenesis, connective tissue growth factors, wingless homologs (Wnts), and integrins. Here, we provide a synopsis of the stromal-epithelial crosstalk in PCa focusing on the relevant molecular biomarkers pertaining to the tumor microenvironment and their role in diagnosis, prognosis, and therapy development.
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影响因子：
5.6
作者：
Bilani N;Bahmad H;Abou-Kheir W
通讯作者：
Abou-Kheir W
影响因子：
4.7
作者：
Bahmad HF;Cheaito K;Chalhoub RM;Hadadeh O;Monzer A;Ballout F;El-Hajj A;Mukherji D;Liu YN;Daoud G;Abou-Kheir W
通讯作者：
Abou-Kheir W
影响因子：
50.3
作者：
Casanovas, O;Hicklin, DJ;Hanahan, D
通讯作者：
Hanahan, D
影响因子：
4.6
作者：
Bahmad, Hisham F.;Samman, Houda;Abou-Kheir, Wassim
通讯作者：
Abou-Kheir, Wassim
影响因子：
--
作者：
Akl MR;Nagpal P;Ayoub NM;Tai B;Prabhu SA;Capac CM;Gliksman M;Goy A;Suh KS
通讯作者：
Suh KS