Recent advances in X-chromosome inactivation.

Recent advances in X-chromosome inactivation.
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X染色体灭活的最新进展。

DOI:
10.1002/jcp.22673
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发表时间:
2011-07
影响因子:
5.6
通讯作者:
Kalantry, Sundeep
Kalantry, Sundeep
中科院分区:
生物学2区
文献类型:
--
作者:
Kalantry, Sundeep

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X-chromosome inactivation is a paradigmatic epigenetic phenomenon that results in the mitotically heritable transcriptional inactivation of one X-chromosome in female mammals, thereby equalizing X-linked gene dosage between the sexes. The epigenetic factors and mechanisms that execute X-inactivation overlap with those that regulate embryonic development and disease progression, thus offering a window into the epigenetic processes that regulate development and disease. Here I summarize some recent developments as well as open questions in X-inactivation research.
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