Molecular imaging of pediatric brain tumors: comparison of tumor metabolism using ¹⁸F-FDG-PET and MRSI.
Molecular imaging of pediatric brain tumors: comparison of tumor metabolism using ¹⁸F-FDG-PET and MRSI.
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DOI：
10.1007/s11060-012-0918-0
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发表时间：
2012-09
影响因子：
3.9
通讯作者：
Warren, Katherine E.
中科院分区：
文献类型：
--
作者：
Hipp, Sean J.;Steffen-Smith, Emilie A.;Patronas, Nicholas;Herscovitch, Peter;Solomon, Jeffrey M.;Bent, Robyn S.;Steinberg, Seth M.;Warren, Katherine E.
磁共振波谱成像（MRSI）和18 F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）是非侵入性成像技术，通常用于评估成人脑肿瘤的恶性程度。我们使用FDG-PET和MRSI比较了小儿脑肿瘤的代谢活性。诊断为原发性脑肿瘤的儿童（n=37）在两周内接受了FDG-PET和MRSI。使用MRSI上的最大胆碱：N-乙酰基-谷氨酸（Cho：NAA）和FDG-PET上的最高肿瘤摄取将肿瘤代谢分类为非活性、活性或高度活性。使用逐体素比较来评估具有最大异常代谢的区域。使用一致性百分比和kappa统计量（κ）评估方法之间的一致性。在FDG-PET和MRSI研究中，儿童脑肿瘤的代谢是异质的。与FDG-PET相比，使用MRSI更频繁地观察到活跃的肿瘤代谢，肿瘤分类的一致性较弱（κ=0.16，p=0.12），一致性为42%（95% CI= 25 - 61%）。用于识别最大代谢活性区域的体素比较显示，大多数研究（62%）重叠，但技术之间的准确一致性较低（29.4%，95% CI = 15.1 - 47.5%）。这些结果表明，FDG-PET和MRSI检测相似，但并不总是相同的肿瘤活动的区域，有两种技术之间的肿瘤代谢活动的程度很少协议。
Magnetic resonance spectroscopic imaging (MRSI) and 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) are non-invasive imaging techniques routinely used to evaluate tumor malignancy in adults with brain tumors. We compared the metabolic activity of pediatric brain tumors using FDG-PET and MRSI. Children (n=37) diagnosed with a primary brain tumor underwent FDG-PET and MRSI within two weeks of each other. Tumor metabolism was classified as inactive, active or highly active using the maximum choline:N-acetyl-asparate (Cho:NAA) on MRSI and the highest tumor uptake on FDG-PET. A voxel-wise comparison was used to evaluate the area with the greatest abnormal metabolism. Agreement between methods was assessed using the percent agreement and the kappa statistic (κ). Pediatric brain tumors were metabolically heterogeneous on FDG-PET and MRSI studies. Active tumor metabolism was observed more frequently using MRSI compared to FDG-PET, and agreement in tumor classification was weak (κ=0.16, p=0.12), with 42% agreement (95% CI= 25 – 61%). Voxel-wise comparison for identifying the area of greatest metabolic activity showed overlap in the majority (62%) of studies, though exact agreement between techniques was low (29.4%, 95% CI = 15.1 – 47.5%). These results indicate that FDG-PET and MRSI detect similar but not always identical regions of tumor activity, and there is little agreement in the degree of tumor metabolic activity between the two techniques.
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影响因子：
6.2
作者：
Tzika, AA;Astrakas, LG;Black, PM
通讯作者：
Black, PM
影响因子：
4.8
作者：
Verma, Ragini;Zacharaki, Evangelia I.;Ou, Yangming;Cai, Hongmin;Chawla, Sanjeev;Lee, Seung-Koo;Melhem, Elias R.;Wolf, Ronald;Davatzikos, Christos
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Davatzikos, Christos
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2.3
作者：
Horská A;Barker PB
通讯作者：
Barker PB
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作者：
Utriainen, M;Metsähonkala, L;Minn, H
通讯作者：
Minn, H
影响因子：
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作者：
Astrakas, LG;Zurakowski, D;Black, PM
通讯作者：
Black, PM