Imaging of brain tumors: MR spectroscopy and metabolic imaging.
Imaging of brain tumors: MR spectroscopy and metabolic imaging.
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DOI：
10.1016/j.nic.2010.04.003
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发表时间：
2010-08
影响因子：
2.3
通讯作者：
Barker PB
中科院分区：
文献类型：
--
作者：
Horská A;Barker PB
人脑的局部质子 MR 波谱 (MRS) 于 20 多年前首次报道，(1–3) 是一种成熟的方法，在全球许多医疗中心临床上用于评估脑肿瘤。(4) 虽然已经使用磷 (31P) 和钠 (11Na) 等异核对人脑肿瘤进行了研究，(5, 6) 迄今为止，大多数波谱研究使用质子 (1H) 核，因为其灵敏度高且易于实施在商用 MRI 扫描仪上。因此，本综述将重点关注人脑肿瘤中的质子 MRS。MR 波谱有两类空间定位技术：单体素（SV）技术（常用的方法包括“PRESS”（7）和“STEAM”（8））一次记录大脑一个区域的光谱，或多体素技术（“MR光谱成像”（MRSI），也称为“化学位移成像”（CSI）（9））同时记录多个区域的光谱，从而绘制出大脑内代谢物的空间分布。 MRSI 通常在 2 维或 3 维中进行，但通常不包括完整的大脑覆盖。虽然 SV-MRS 和 MRSI 各有其优点和缺点（例如在光谱质量、扫描时间、空间分辨率、空间覆盖范围和易用性/解释方面），但脑肿瘤的一个关键考虑因素是其代谢不均匀性。例如，高级脑肿瘤坏死核心的光谱与活跃生长边缘的光谱有很大不同，而肿瘤周围水肿则与肿瘤侵入周围脑组织不同；由于这些原因和其他原因，高分辨率 MRSI 通常更适合评估脑肿瘤代谢。有关 SV-MRS 和 MRSI 相对优点的详细讨论，请参阅参考文献。(10)
Localized proton MR spectroscopy (MRS) of the human brain, first reported more than 20 years ago,(1–3) is a mature methodology that is used clinically in many medical centers worldwide for the evaluation of brain tumors.(4) While there have been studies of human brain tumors using heteronuclei such as phosphorus (31P) and sodium (11Na),(5, 6) by far the most spectroscopy studies use the proton (1H) nucleus, because of both its high sensitivity and ease of implementation on commercial MRI scanners. This review will therefore focus on proton MRS in human brain tumors.There are two classes of spatial localization techniques for MR spectroscopy; single-voxel (SV) techniques (commonly used methods includes ‘PRESS’(7) and ‘STEAM’(8)) which record spectra from one region of the brain at a time, or multi-voxel techniques (‘MR spectroscopic imaging’(MRSI), also called ‘Chemical Shift Imaging’(CSI)(9)) which simultaneously record spectra from multiple regions and thereby map out the spatial distribution of metabolites within the brain. MRSI is typically performed in 2-or 3-dimensions, but does not usually include full brain coverage. While SV-MRS and MRSI each have their own advantages and disadvantages (eg in terms of spectral quality, scan time, spatial resolution, spatial coverage, and ease of use/interpretation), a key consideration for brain tumors is their metabolic inhomogeneity. For instance, the spectrum from the necrotic core of a high-grade brain tumor is quite different from a spectrum from the actively growing rim, while peri-tumoral edema is different from tumor invasion into surrounding brain tissue; for these reasons and others, high-resolution MRSI is often favored for evaluating brain tumor metabolism. For a detailed discussion of the relative merits of SV-MRS and MRSI, please see reference.(10)
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DOI：
10.1073/pnas.82.7.2148
发表时间：
1985-01-01
影响因子：
11.1
作者：
BOTTOMLEY, PA;EDELSTEIN, WA;ADAMS, WA
通讯作者：
ADAMS, WA
影响因子：
2.9
作者：
Arnold, D L;Shoubridge, E A;Feindel, W
通讯作者：
Feindel, W
影响因子：
19.7
作者：
BRUHN, H;FRAHM, J;HAMBURGER, C
通讯作者：
HAMBURGER, C
影响因子：
11.2
作者：
De Stefano, N;Caramanos, Z;Arnold, DL
通讯作者：
Arnold, DL
影响因子：
3.3
作者：
Demir, Mustafa Kemal;Iplikcioglu, A. Celal;Sav, Aydin
通讯作者：
Sav, Aydin