Neonatal sensory nerve injury-induced synaptic plasticity in the trigeminal principal sensory nucleus.
Neonatal sensory nerve injury-induced synaptic plasticity in the trigeminal principal sensory nucleus.
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DOI：
10.1016/j.expneurol.2015.04.022
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发表时间：
2016-01
影响因子：
5.3
通讯作者：
Erzurumlu RS
中科院分区：
文献类型：
--
作者：
Lo FS;Erzurumlu RS
新生儿哺乳动物的感觉剥夺研究，如单眼闭眼、须修剪、嗅觉上皮的化学阻断，揭示了在不同的关键时期，感觉输入在大脑布线中的重要性。但很少有研究关注新生儿外周感觉神经损伤对中枢神经系统（CNS）回路突触布线的影响。外周体感觉神经与其他特殊感觉传入神经的不同之处在于，由于其在体内的位置，它们更容易受到挤压或断裂。与视觉和听觉传入神经不同，这些神经在受损后表现出再生能力。独特的是，体感觉周围神经的损伤不仅会阻断来自感觉受体的活动，还会通过初级感觉神经元未受损的中央轴突向大脑介导损伤诱导的神经和胶质化学信号。这些化学信号比单独的感官封锁有更多更持久的影响。在这里，我们回顾研究的重点是新生儿周围感觉神经损伤的后果在脑干三叉神经复合体的主要感觉核。
Sensory deprivation studies in neonatal mammals, such as monocular eye closure, whisker trimming, chemical blockade of the olfactory epithelium have revealed the importance of sensory inputs in brain wiring during distinct critical periods. But very few studies have paid attention to the effects of neonatal peripheral sensory nerve damage on synaptic wiring of the central nervous system (CNS) circuits. Peripheral somatosensory nerves differ from other special sensory afferents in that they are more prone to crush or severance because of their locations in the body. Unlike the visual and auditory afferents, these nerves show regenerative capabilities after damage. Uniquely, damage to a somatosensory peripheral nerve does not only block activity incoming from the sensory receptors but also mediates injury-induced neuro- and glial chemical signals to the brain through the uninjured central axons of the primary sensory neurons. These chemical signals can have both far more and longer lasting effects than sensory blockade alone. Here we review studies which focus on the consequences of neonatal peripheral sensory nerve damage in the principal sensory nucleus of the brainstem trigeminal complex.
影响因子：
5.3
作者：
Sanchez-Jimenez A;Torets C;Panetsos F
通讯作者：
Panetsos F