Complementary processing of haptic information by slowly and rapidly adapting neurons in the trigeminothalamic pathway. Electrophysiology, mathematical modeling and simulations of vibrissae-related neurons.
Complementary processing of haptic information by slowly and rapidly adapting neurons in the trigeminothalamic pathway. Electrophysiology, mathematical modeling and simulations of vibrissae-related neurons.
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DOI：
10.3389/fncel.2013.00079
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发表时间：
2013
影响因子：
5.3
通讯作者：
Panetsos F
中科院分区：
文献类型：
--
作者：
Sanchez-Jimenez A;Torets C;Panetsos F
强直（缓慢适应）和相位（快速适应）初级传入向中枢神经系统传递触觉信息的互补方面：前者是物体的位置和纹理，后者是形状。在体感觉通路的所有中继站中也记录了强直和相位神经反应，但它们在信息处理和信息传递到皮层中的作用尚不清楚：我们不知道强直和相位神经元是否处理触觉信息的互补方面和/或这两种类型是否构成两个独立的通道，将触觉信息的互补方面传递到皮层。在此，我们提出在大鼠三叉神经快速通路（PrV-VPM：三叉神经主核-丘脑腹后内侧核）中阐明这两个问题。我们分析了在1-40 Hz的触须刺激下，在对照组和去皮动物中，PrV和内侧小网膜中单个细胞的早期和整体行为、潜伏期和稳定性，我们使用随机尖峰模型和广泛的模拟。我们的研究结果强烈表明，在躯体感觉系统（PrV）的第一个中继站中：(1)强直和相相神经元处理与须相关的触觉信息的互补方面(2)强直和相相反应不是来自两种不同类型的神经元(3)这两种反应是由体感觉皮层对一种独特类型的PrV细胞的不同作用产生的(4)强直和相相神经元不属于向丘脑传递触觉信息的两个不同通道(5)三叉丘脑的传递是完全由三叉丘脑完成的强直放电神经元和(6)触觉信息的所有方面被编码成强直放电神经元的低通、带通和高通滤波剖面。我们的研究结果对于神经回路和信息处理的基础研究以及感觉神经假体的发展都具有重要的意义。
Tonic (slowly adapting) and phasic (rapidly adapting) primary afferents convey complementary aspects of haptic information to the central nervous system: object location and texture the former, shape the latter. Tonic and phasic neural responses are also recorded in all relay stations of the somatosensory pathway, yet it is unknown their role in both, information processing and information transmission to the cortex: we don't know if tonic and phasic neurons process complementary aspects of haptic information and/or if these two types constitute two separate channels that convey complementary aspects of tactile information to the cortex. Here we propose to elucidate these two questions in the fast trigeminal pathway of the rat (PrV-VPM: principal trigeminal nucleus-ventroposteromedial thalamic nucleus). We analyze early and global behavior, latencies and stability of the responses of individual cells in PrV and medial lemniscus under 1–40 Hz stimulation of the whiskers in control and decorticated animals and we use stochastic spiking models and extensive simulations. Our results strongly suggest that in the first relay station of the somatosensory system (PrV): (1) tonic and phasic neurons process complementary aspects of whisker-related tactile information (2) tonic and phasic responses are not originated from two different types of neurons (3) the two responses are generated by the differential action of the somatosensory cortex on a unique type of PrV cell (4) tonic and phasic neurons do not belong to two different channels for the transmission of tactile information to the thalamus (5) trigeminothalamic transmission is exclusively performed by tonically firing neurons and (6) all aspects of haptic information are coded into low-pass, band-pass, and high-pass filtering profiles of tonically firing neurons. Our results are important for both, basic research on neural circuits and information processing, and development of sensory neuroprostheses.
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影响因子：
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通讯作者：
Simons, DJ
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