Thymidine phosphorylase gene variant, platelet counts and survival in gastrointestinal cancer patients treated by fluoropyrimidines.
Thymidine phosphorylase gene variant, platelet counts and survival in gastrointestinal cancer patients treated by fluoropyrimidines.
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DOI：
10.1038/srep05697
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发表时间：
2014-07-16
影响因子：
4.6
通讯作者：
Yuan X
中科院分区：
文献类型：
--
作者：
Huang L;Chen F;Chen Y;Yang X;Xu S;Ge S;Fu S;Chao T;Yu Q;Liao X;Hu G;Zhang P;Yuan X
胸苷磷酸化酶基因变异（TP，又称血小板源性内皮细胞生长因子）和血小板增多症的预测价值在胃肠道癌（GIC）患者中存在争议，值得进一步研究。我们筛选了所有氟嘧啶（FU）通路基因（包括TP、TS、ENOSF1和DPD）的常见错义单核苷酸多态性（MAF≥0.1）。选取其中3例，使用Sequenom MassARRAY对141例GIC患者进行基因分型。免疫组织化学检测TP表达。我们的目的是评估研究基因和血小板计数在GIC患者中的预后意义。多因素分析显示，rs11479-T等位基因携带者血小板计数与总生存率呈负相关。此外，TP: rs11479的T等位基因与TP在癌组织中的高表达相关。我们认为TP: rs11479变异结合血小板计数可能是对接受一线FU化疗的GIC患者的有效预后指标，对于携带rs11479 T等位基因的患者应谨慎使用血小板生成素因子。
The predictive value of thymidine phosphorylase gene variants (TP, also called platelet-derived endothelial cell growth factor) and thrombocytosis were controversial and worthy of further study in gastrointestinal cancer (GIC) patients. We screened all of the common missense single nucleotide polymorphisms (MAF ≥ 0.1) in fluoropyrimidines (FU) pathway genes (including TP, TS, ENOSF1 and DPD). Three of them were selected and genotyped using Sequenom MassARRAY in 141 GIC patients. TP expression was assessed by immunohistochemistry. Our aim was to evaluate the prognostic significance of studied genes and platelet counts in GIC patients. Multivariate analyses indicated in rs11479-T allele carriers, platelet counts negatively correlated to overall survival. In addition, T allele of TP: rs11479 was associated with higher TP expression in cancer tissues. We suggest TP: rs11479 variant combined with platelet counts may be useful prognostic makers in GIC patients receiving first-line FU chemotherapy and thrombopoietin factor should be used with caution in the rs11479 T allele bearing patients.
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影响因子：
45.3
作者：
Meropol, Neal J.;Gold, Philip J.;Schwarting, Roland
通讯作者：
Schwarting, Roland
影响因子：
3.7
作者：
Jennings BA;Loke YK;Skinner J;Keane M;Chu GS;Turner R;Epurescu D;Barrett A;Willis G
通讯作者：
Willis G
影响因子：
50.5
作者：
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通讯作者：
Hecker, H
影响因子：
3
作者：
Farina-Sarasqueta, Arantza;van Lijnschoten, Gesina;van den Brule, Adriaan J. C.
通讯作者：
van den Brule, Adriaan J. C.
影响因子：
15.3
作者：
Nyasavajjala, Sitaramachandra Murthy;Runau, Francois;Lund, Jonathan N.
通讯作者：
Lund, Jonathan N.