Homocysteine is transported by the microvillous plasma membrane of human placenta.
Homocysteine is transported by the microvillous plasma membrane of human placenta.
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DOI：
10.1007/s10545-010-9141-3
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发表时间：
2011-02
影响因子：
4.2
通讯作者：
Glazier, Jocelyn D.
中科院分区：
文献类型：
--
作者：
Tsitsiou, Eleni;Sibley, Colin P.;D'Souza, Stephen W.;Catanescu, Otilia;Jacobsen, Donald W.;Glazier, Jocelyn D.
母体血浆同型半胱氨酸（Hcy）浓度升高与妊娠并发症和不良新生儿结局相关。我们希望在这里提出的假设是，胎盘运输的同型半胱氨酸，通过竞争与内源性氨基酸的转运活性，可能占一些破坏性的影响同型半胱氨酸对胎盘的代谢和功能，以及胎儿的发展。在这篇文章中，我们提供了一个概述最近的一些研究特点的运输机制，同型半胱氨酸跨微绒毛质膜（MVM）的合胞体滋养层，运输上皮细胞的人胎盘。已经鉴定了三种Hcy转运系统，系统L、A和y+L。这是使用竞争性抑制策略完成的，以研究Hcy对每个转运系统的充分表征的放射性标记底物摄取到分离的MVM囊泡中的影响。还进行了反向实验，检查模型底物对[35 S]L-Hcy摄取的影响。本文描述了L、A和y+L系统参与胎盘同型半胱氨酸转运的证据，并讨论了这些发现对胎盘功能和胎儿发育的生理意义。
Elevated maternal plasma concentrations of homocysteine (Hcy) are associated with pregnancy complications and adverse neonatal outcomes. The postulate that we wish to advance here is that placental transport of Hcy, by competing with endogenous amino acids for transporter activity, may account for some of the damaging impacts of Hcy on placental metabolism and function as well as fetal development. In this article, we provide an overview of some recent studies characterising the transport mechanisms for Hcy across the microvillous plasma membrane (MVM) of the syncytiotrophoblast, the transporting epithelium of human placenta. Three Hcy transport systems have been identified, systems L, A and y+L. This was accomplished using a strategy of competitive inhibition to investigate the effects of Hcy on the uptake of well-characterised radiolabelled substrates for each transport system into isolated MVM vesicles. The reverse experiments were also performed, examining the effects of model substrates on [35S]L-Hcy uptake. This article describes the evidence for systems L, A and y+L involvement in placental Hcy transport and discusses the physiological implications of these findings with respect to placental function and fetal development.
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DOI：
10.1152/ajpcell.2000.278.6.c1162
发表时间：
2000-06-01
影响因子：
5.5
作者：
Ayuk, PTY;Sibley, CP;Glazier, JD
通讯作者：
Glazier, JD
影响因子：
5.5
作者：
Greenwood, SL;Clarson, LH;Sibley, CP
通讯作者：
Sibley, CP
影响因子：
4.1
作者：
GANAPATHY, ME;LEIBACH, FH;GANAPATHY, V
通讯作者：
GANAPATHY, V
影响因子：
3.6
作者：
Di Simone, N;Maggiano, N;Caruso, A
通讯作者：
Caruso, A
DOI：
10.1002/bdrc.20037
发表时间：
2005-06-01
期刊：
Birth defects research. Part C, Embryo today : reviews
影响因子：
--
作者：
Dean, Wendy;Lucifero, Diana;Santos, Fatima
通讯作者：
Santos, Fatima