Dynamic changes of peripheral blood lymphocyte subsets in acute ischemic stroke and prognostic value.
Dynamic changes of peripheral blood lymphocyte subsets in acute ischemic stroke and prognostic value.
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急性缺血性脑卒中外周血淋巴细胞亚群的动态变化及预后价值
DOI：
10.1002/brb3.1919
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发表时间：
2021-01
影响因子：
3.1
通讯作者：
Tian DS
中科院分区：
文献类型：
--
作者：
Xiao J;Qiu QW;Qin C;Tao R;Qiao SY;Chen M;Pan DJ;Tian DS
探讨急性缺血性脑卒中（AIS）患者外周血淋巴细胞亚群的动态变化及其与脑卒中严重程度和远期预后的关系。共招募了96名AIS连续患者和28名年龄和性别匹配的健康对照。采集外周血，用流式细胞仪分析淋巴细胞亚群的百分比。观察两组患者淋巴细胞亚群的动态变化及其与临床指标的相关性，如发病时的美国国立卫生研究院卒中量表（NIHSS）评分和3个月后的改良兰金量表（mRS）评分。在我们的研究中，我们观察到与对照组相比，AIS患者中T淋巴细胞（T细胞）、辅助/诱导T淋巴细胞（Th细胞）和抑制/细胞毒性T淋巴细胞（Ts细胞）的百分比降低。脑卒中后第8-14天，NIHSS ≤4分组T细胞和Ts细胞频率明显高于NIHSS >4分组。脑卒中后1- 3d mRS ≤2组的T细胞和Th细胞百分比均高于mRS >2组。AIS中T细胞、Th细胞和Ts细胞的频率在卒中后至少14天显著下降。中风后第8-14天T细胞和Ts细胞的频率较低代表病情较严重，中风后72小时内T细胞和Th细胞的百分比与3个月的结果呈负相关，这可能具有预测中风长期预后的潜力。在这项工作中，我们前瞻性地招募了缺血性卒中发病14天内入院的患者，并研究了不同梗死时间外周血淋巴细胞亚群的时间动态变化与卒中临床严重程度和预后的关系，旨在确定AIS患者的潜在预后价值。
To explore dynamic changes of peripheral blood lymphocyte subsets in patients with acute ischemic stroke (AIS) and the relationship with stroke severity and long‐term outcomes. A total of 96 consecutive patients with AIS and 28 age‐ and gender‐matched healthy controls were recruited. Peripheral blood samples were collected, and the percentages of lymphocyte subsets were analyzed by flow cytometry. The dynamic changes in lymphocyte subsets and their correlation with clinical parameters, such as National Institutes of Health Stroke Scale (NIHSS) scores at onset and modified Rankin scale (mRS) scores 3 months later, were evaluated. In our study, we observed a decrease in the percentages of T‐lymphocytes (T cells), helper/inducible T‐lymphocytes (Th cells) and suppressor/cytotoxic T‐lymphocytes (Ts cells) in AIS patients as compared to controls. The frequencies of T cells and Ts cells on day 8–14 after stroke in NIHSS ≤4 group were significantly higher than those in NIHSS >4 group. The percentages of T cells and Th cells on day 1–3 after stroke in the mRS ≤2 group were higher than those in the mRS >2 group. The frequencies of T cells, Th cells, and Ts cells in AIS are declined dramatically at least 14 days after stroke. Lower frequencies of T cells and Ts cells on day 8–14 after stroke represent more severe disease conditions, and the percentages of T cells and Th cells within 72 hr after stroke are negatively correlated with 3‐month outcomes, which might have a potential for predicting long‐term prognosis of stroke. In this work, we prospectively enrolled patients admitted within 14 days of ischemic stroke onset and investigated the temporal dynamic changes of peripheral blood lymphocyte subsets over different infarction time in relation to clinical severity and prognosis of stroke, aiming to identify the potential prognostic value in patients with AIS.
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影响因子：
1.6
作者：
Tuttolomondo A;Pecoraro R;Casuccio A;Di Raimondo D;Buttà C;Clemente G;Corte VD;Guggino G;Arnao V;Maida C;Simonetta I;Maugeri R;Squatrito R;Pinto A
通讯作者：
Pinto A
影响因子：
3.7
作者：
Vogelgesang A;May VE;Grunwald U;Bakkeboe M;Langner S;Wallaschofski H;Kessler C;Bröker BM;Dressel A
通讯作者：
Dressel A
影响因子：
8.3
作者：
Liesz, Arthur;Hagmann, Sebastien;Veltkamp, Roland
通讯作者：
Veltkamp, Roland
影响因子：
2.6
作者：
Posová H;Horáková D;Čapek V;Uher T;Hrušková Z;Havrdová E
通讯作者：
Havrdová E
DOI：
10.1084/jem.20021098
发表时间：
2003-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Prass K;Meisel C;Höflich C;Braun J;Halle E;Wolf T;Ruscher K;Victorov IV;Priller J;Dirnagl U;Volk HD;Meisel A
通讯作者：
Meisel A