The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia.
The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia.
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DOI：
10.1016/j.diagmicrobio.2016.06.008
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发表时间：
2016-09
影响因子：
2.9
通讯作者：
Leggett J
中科院分区：
文献类型：
--
作者：
Gilbert D;Gelfer G;Wang L;Myers J;Bajema K;Johnston M;Leggett J
对 127 名因社区获得性肺炎 (CAP) 入院的可评估患者的两个诊断包进行了比较。所有患者的诊断方式包括痰培养（如果可获得）和血液、尿液培养，以检测肺炎链球菌和嗜肺军团菌抗原，以及鼻拭子，以检测肺炎链球菌和金黄色葡萄球菌的 PCR 探针。所有患者至少测量一种降钙素原水平。对于病毒检测，患者被随机分配到实验室生成的 5 种病毒 PCR 组或更广泛、更快的 FilmArray PCR 组。总体而言，71% 的患者得到了病因诊断。 39% 的人检测到呼吸道病毒。在 25 名仅检测到呼吸道病毒且 PCT 水平正常的患者中，改善抗生素管理的潜力是显而易见的。
Two diagnostic bundles were compared in 127 evaluable patients admitted with community-acquired pneumonia (CAP). Diagnostic modalities in all patients included cultures of sputum (if obtainable) and blood, urine for detection of the antigens of Streptococcus pneumoniae and Legionella pneumophila, and nasal swabs for PCR probes for S. pneumoniae and Staphylococcus aureus. At least one procalcitonin level was measured in all patients. For virus detection, patients were randomized to either a 5-virus, lab-generated PCR panel or the broader and faster FilmArray PCR panel. Overall, an etiologic diagnosis was established in 71% of the patients. A respiratory virus was detected in 39%. The potential for improved antibiotic stewardship was evident in 25 patients with only detectable respiratory virus and normal levels of PCT.
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影响因子：
3.7
作者：
Said MA;Johnson HL;Nonyane BA;Deloria-Knoll M;O'Brien KL;AGEDD Adult Pneumococcal Burden Study Team;Andreo F;Beovic B;Blanco S;Boersma WG;Boulware DR;Butler JC;Carratalà J;Chang FY;Charles PG;Diaz AA;Domínguez J;Ehara N;Endeman H;Falcó V;Falguera M;Fukushima K;Garcia-Vidal C;Genne D;Guchev IA;Gutierrez F;Hernes SS;Hoepelman AI;Hohenthal U;Johansson N;Kolek V;Kozlov RS;Lauderdale TL;Mareković I;Masiá M;Matta MA;Miró Ò;Murdoch DR;Nuermberger E;Paolini R;Perelló R;Snijders D;Plečko V;Sordé R;Strålin K;van der Eerden MM;Vila-Corcoles A;Watt JP
通讯作者：
Watt JP
DOI：
10.1016/j.diagmicrobio.2015.08.001
发表时间：
2015-12
影响因子：
2.9
作者：
Gelfer G;Leggett J;Myers J;Wang L;Gilbert DN
通讯作者：
Gilbert DN
影响因子：
11.8
作者：
Gilbert, David N.
通讯作者：
Gilbert, David N.
影响因子：
9.4
作者：
Albrich, Werner C.;Madhi, Shabir A.;Klugman, Keith P.
通讯作者：
Klugman, Keith P.
影响因子：
11.8
作者：
Schuetz, Philipp;Briel, Matthias;Mueller, Beat
通讯作者：
Mueller, Beat