Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review.
Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review.
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慢加急性肝衰竭动物模型的展望：小综述
DOI：
10.14218/jcth.2022.00086
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发表时间：
2022-10-28
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性加急性肝衰竭（ACLF）是慢性肝病患者在突发事件后发生的一种临床综合征，与全身性多器官衰竭导致的高死亡率相关。建立一个合适的和稳定的动物模型，以准确地阐明ACLF发病机制的分子基础是至关重要的，有效的早期诊断和治疗策略的发展。在这种情况下，本文提供了一个简洁和包容性的审查ACLF动物模型的发展取得的突破。
Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.
影响因子：
4.6
作者：
Xiping Z;Ke W;Yaping Y;Hongchan Z;Qihui C
通讯作者：
Qihui C