Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice.
Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice.
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DOI：
10.1155/2010/757191
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发表时间：
2010
影响因子：
4.6
通讯作者：
Qihui C
中科院分区：
文献类型：
--
作者：
Xiping Z;Ke W;Yaping Y;Hongchan Z;Qihui C
Objective.目的：探讨黄芪注射液对梗阻性黄疸（OJ）大鼠肠粘膜的保护作用及其机制。方法.将大鼠随机分为假手术组、模型对照组和丹参治疗组。分别于术后7 d、14 d、21 d、28 d观察肠黏膜病理变化、Bax、NF-κB蛋白表达水平、肠黏膜细胞凋亡指数及血清NO、MDA、SOD含量。结果治疗组7、14 d肠黏膜病理评分、14 d肠黏膜细胞凋亡指数及14 d血清MDA含量均显著低于模型对照组（P <0.05）。治疗组各时间点血清SOD含量均显著高于模型对照组（P <0.05）。假手术组（21 d）Bax蛋白染色强度和阳性率乘积均显著低于模型对照组（P <0.05）。结论丹参注射液可通过增加SOD含量、降低MDA含量、抑制细胞凋亡、减轻肠黏膜病理改变，对OJ大鼠肠黏膜具有保护作用。
Objective. To research the protective effects and mechanisms of Radix Astragali injection on the intestinal mucosa of rats with obstructive jaundice (OJ). Methods. The rats were randomly divided into sham-operated, model control and Radix Astragali treated group. We observed the pathological changes of intestinal mucosa, expression levels of Bax and NF-κB proteins, and apoptosis indexes in intestinal mucosa as well as serum NO, MDA and SOD contents, respectively, on 7d, 14d, 21d and 28d after operation. Results. The pathological severity score (on 7d and 14d), apoptotic indexes (on 14d) of the intestinal mucosa and serum MDA content (on 14d) of treated group were significantly lower than those in the model control group (P < .05). The serum SOD contents (on all time points) of treated group were significantly higher than those in the model control group (P < .05). The sham-operated group (on 21d) of the product of staining intensity and positive rate of Bax protein was significantly lower than model control group (P < .05). Conclusion. Radix Astragali injection could protect the intestinal mucosa of OJ rats by increasing the content of SOD, reducing the content of MDA, inhibiting the apoptosis and relieving the pathological changes of intestinal mucosa.
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影响因子：
2.2
作者：
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通讯作者：
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