Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study.
Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study.
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DOI：
10.1016/j.ijid.2021.07.016
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Guiot J
中科院分区：
文献类型：
--
作者：
Darcis G;Bouquegneau A;Maes N;Thys M;Henket M;Labye F;Rousseau AF;Canivet P;Desir C;Calmes D;Schils R;De Worm S;Léonard P;Meunier P;Moutschen M;Louis R;Guiot J
感染严重急性呼吸综合征冠状病毒-2 （SARS-CoV-2）后，各种症状和相当大的器官功能障碍持续存在。潜在的中长期健康后遗症仍不确定。这项前瞻性研究针对比利时li<e:1>大学医院2019冠状病毒病（COVID-19）住院患者，旨在确定COVID-19的持续后果。前瞻性招募了2020年3月2日至10月1日期间住院的中重度确诊COVID-19患者。出院后3个月和6个月的随访包括人口统计学和临床数据、生物学数据、肺功能测试（PFTs）和胸部高分辨率计算机断层扫描（CT）。总共有199人被纳入分析。大多数患者接受补氧（80.4%）。出院6个月后，仍有47%和32%的患者存在劳累性呼吸困难和疲劳。3个月随访时pfs显示一氧化碳扩散能力降低（平均71.6±18.6%），6个月随访时明显增加（P<0.0001）。胸部CT扫描显示高患病率（68.9%的队列）持续异常，主要是磨玻璃混浊。住院时间、重症监护病房入住时间和机械通气与出院后3个月症状持续无相关性。COVID-19住院后持续症状的发生率高且在出院后6个月内保持稳定。然而，随着时间的推移，生物学、功能和影像学异常明显改善。
Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- and long-term health sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 (COVID-19) in Liège University Hospital, Belgium aimed to determine the persistent consequences of COVID-19. Patients admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between 2 March and 1 October 2020, were recruited prospectively. Follow-up at 3 and 6 months after hospital discharge included demographic and clinical data, biological data, pulmonary function tests (PFTs) and high-resolution computed tomography (CT) scans of the chest. In total, 199 individuals were included in the analysis. Most patients received oxygen supplementation (80.4%). Six months after discharge, 47% and 32% of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion capacity of carbon monoxide (mean 71.6 ± 18.6%), and this increased significantly at 6-month follow-up (P<0.0001). Chest CT scans showed a high prevalence (68.9% of the cohort) of persistent abnormalities, mainly ground glass opacities. Duration of hospitalization, intensive care unit admission and mechanical ventilation were not associated with the persistence of symptoms 3 months after discharge. The prevalence of persistent symptoms following hospitalization with COVID-19 is high and stable for up to 6 months after discharge. However, biological, functional and iconographic abnormalities improved significantly over time.
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影响因子：
4.6
作者：
Kashif A;Chaudhry M;Fayyaz T;Abdullah M;Malik A;Anwer JMA;Inam SHA;Fatima T;Iqbal N;Shoaib K
通讯作者：
Shoaib K
DOI：
10.1186/cc11454
发表时间：
2013-02-04
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kellum JA;Lameire N;KDIGO AKI Guideline Work Group
通讯作者：
KDIGO AKI Guideline Work Group
纽约市Covid-19危重疾病患者急性肾脏损伤的发生率降低。
影响因子：
6
作者：
Charytan DM;Parnia S;Khatri M;Petrilli CM;Jones S;Benstein J;Horwitz LI
通讯作者：
Horwitz LI
影响因子：
13.8
作者：
Bellan M;Soddu D;Balbo PE;Baricich A;Zeppegno P;Avanzi GC;Baldon G;Bartolomei G;Battaglia M;Battistini S;Binda V;Borg M;Cantaluppi V;Castello LM;Clivati E;Cisari C;Costanzo M;Croce A;Cuneo D;De Benedittis C;De Vecchi S;Feggi A;Gai M;Gambaro E;Gattoni E;Gramaglia C;Grisafi L;Guerriero C;Hayden E;Jona A;Invernizzi M;Lorenzini L;Loreti L;Martelli M;Marzullo P;Matino E;Panero A;Parachini E;Patrucco F;Patti G;Pirovano A;Prosperini P;Quaglino R;Rigamonti C;Sainaghi PP;Vecchi C;Zecca E;Pirisi M
通讯作者：
Pirisi M
影响因子：
64.8
作者：
Al-Aly, Ziyad;Xie, Yan;Bowe, Benjamin
通讯作者：
Bowe, Benjamin