A classical twin study of PTSD symptoms and resilience: Evidence for a single spectrum of vulnerability to traumatic stress.
A classical twin study of PTSD symptoms and resilience: Evidence for a single spectrum of vulnerability to traumatic stress.
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DOI：
10.1002/da.22712
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发表时间：
2018-03
影响因子：
7.4
通讯作者：
Magruder KM
中科院分区：
文献类型：
--
作者：
Wolf EJ;Miller MW;Sullivan DR;Amstadter AB;Mitchell KS;Goldberg J;Magruder KM
研究PTSD症状和恢复力中共有的遗传和环境风险因素。经典双胞胎研究2010-2012年在越南时代双胞胎登记处的3,318对男性双胞胎中进行的调查数据。分析包括：（a）遗传和环境对PTSD症状严重程度（用PTSD检查表测量）和复原力（用Connor-Davidson复原力量表-10评估）的影响的估计;（B）创伤应激的潜在模型的发展，包括PTSD和复原力;和（c）遗传和环境对这一谱的影响的估计。PTSD的遗传度为49%，心理弹性的遗传度为25%。PTSD和恢复力的相关系数为r =-0.59，其中59%的相关性归因于单一的遗传因素，而其余的则归因于单一的非共享环境因素。复原力也受到与创伤后应激障碍不同的常见和独特环境因素的影响，但没有特定于复原力的遗传因素。解释性因素分析支持修订后的表型的发展，反映了更广泛的创伤性应激，与生物计量模型表明增加遗传性（66%），这一频谱相比，创伤后应激障碍或弹性单独。遗传因素促成了创伤应激反应的单一谱，反映了一端的复原力和另一端的高症状严重性。这对在寻找创伤相关精神病理学的分子遗传标记中进行表型细化具有意义。分子遗传学研究不仅仅关注PTSD的遗传风险，还可以从更广泛的创伤性应激反应的评估中获益。
To examine shared genetic and environmental risk factors across PTSD symptoms and resilience. Classical twin study of 2010–2012 survey data conducted among 3,318 male twin pairs in the Vietnam Era Twin Registry. Analyses included: (a) estimates of genetic and environmental influences on PTSD symptom severity (as measured by the PTSD Checklist) and resilience (assessed with the Connor-Davidson Resilience Scale-10); (b) development of a latent model of traumatic stress, spanning both PTSD and resilience; and (c) estimates of genetic and environmental influences on this spectrum. The heritability of PTSD was 49% and of resilience was 25%. PTSD and resilience were correlated at r = −.59, and 59% of this correlation was attributable to a single genetic factor while the remainder was due to a single non-shared environment factor. Resilience was also influenced by common and unique environmental factors not shared with PTSD, but there was no genetic factor specific to resilience. Confirmatory factor analysis supported development of a revised phenotype reflecting the broader dimension of traumatic stress, with biometric models suggesting increased heritability (66%) of this spectrum compared to PTSD or resilience individually. Genetic factors contribute to a single spectrum of traumatic stress reflecting resilience at one end and high symptom severity at the other. This carries implications for phenotype refinement in the search for molecular genetic markers of trauma-related psychopathology. Rather than focusing only on genetic risk for PTSD, molecular genetics research may benefit from evaluation of the broader spectrum of traumatic stress.
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影响因子：
8.1
作者：
Magruder K;Yeager D;Goldberg J;Forsberg C;Litz B;Vaccarino V;Friedman M;Gleason T;Huang G;Smith N
通讯作者：
Smith N
影响因子：
7.4
作者：
Connor, KM;Davidson, JRT
通讯作者：
Davidson, JRT
DOI：
10.1097/00004850-200501000-00009
发表时间：
2005-01-01
影响因子：
2.6
作者：
Davidson, JRT;Payne, VM;Weisler, RH
通讯作者：
Weisler, RH
影响因子：
0.9
作者：
Forsberg, Christopher W.;Goldberg, Jack;Smith, Nicholas L.
通讯作者：
Smith, Nicholas L.
影响因子：
3.3
作者：
Campbell-Sills, Laura;Stein, Murray B.
通讯作者：
Stein, Murray B.