Neurobiological mechanisms of pain in sickle cell disease.
Neurobiological mechanisms of pain in sickle cell disease.
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DOI：
10.1182/asheducation-2010.1.403
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Molokie R
中科院分区：
文献类型：
--
作者：
Wang ZJ;Wilkie DJ;Molokie R
Pain is a frequent complaint of people living with SCD. The neurobiology of pain in SCD remains poorly understood. Whereas pain of SCD has been thought to be primarily related to visceral and somatic tissue injury subsequent to vaso-occlusion events, emerging evidence from our human and animal studies has suggested that a component of SCD pain may be related to neuropathic processes. Significant knowledge has been obtained from studies of molecular and neurobiological mechanisms leading to and maintaining neuropathic pain. Some of the most promising evidence has implicated major roles of protein kinase C and Ca2+/calmodulin-dependent protein kinase II, and their interaction with of the N-methyl-D-aspartate (NMDA) receptors and the transient receptor potential vanilloid 1 receptor (TRPV1) in the development of neuropathic pain. Latest evidence from our studies suggests that these pathways are important for SCD pain as well. Coupled with the emerging animal models of SCD pain, we can now start to elucidate neurobiological mechanisms underlying pain in SCD, which may lead to better understanding and effective therapies for SCD pain.
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影响因子：
7.6
作者：
ELLIOTT, K;KEST, B;INTURRISI, CE
通讯作者：
INTURRISI, CE
DOI：
10.1124/jpet.107.132167
发表时间：
2008-04-01
影响因子：
3.5
作者：
Luo, Fang;Yang, Cheng;Wang, Zaijie Jim
通讯作者：
Wang, Zaijie Jim
DOI：
10.1523/jneurosci.4346-09.2010
发表时间：
2010-01-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chen Y;Yang C;Wang ZJ
通讯作者：
Wang ZJ
影响因子：
13.9
作者：
Costigan M;Scholz J;Woolf CJ
通讯作者：
Woolf CJ
DOI：
10.1124/jpet.109.152165
发表时间：
2009-08-01
影响因子：
3.5
作者：
Chen, Yan;Luo, Fang;Wang, Zaijie Jim
通讯作者：
Wang, Zaijie Jim