Neuropathic pain: a maladaptive response of the nervous system to damage.
Neuropathic pain: a maladaptive response of the nervous system to damage.
复制标题
DOI：
10.1146/annurev.neuro.051508.135531
复制
发表时间：
2009
影响因子：
13.9
通讯作者：
Woolf CJ
中科院分区：
文献类型：
--
作者：
Costigan M;Scholz J;Woolf CJ
神经性疼痛是由躯体感觉神经系统的损伤引发的，改变其结构和功能，使疼痛自发发生，对有害和无害刺激的反应被病理放大。疼痛是伤害性感觉系统中不适应可塑性的一种表现，一系列变化构成了神经疾病状态。广泛分布于神经系统的多种改变导致了复杂的疼痛表型。这些改变包括动作电位的异位产生，突触传递的易化和去抑制，突触连接的丧失和新突触回路的形成，以及神经免疫相互作用。虽然神经损伤是必要的，但它们不足以产生神经病理性疼痛；基因多态、性别和年龄都会影响发生持续性疼痛的风险。治疗需要从仅仅抑制症状转向旨在预防适应不良可塑性和降低内在风险的疾病修正策略。
Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its structure and function so that pain occurs spontaneously and responses to noxious and innocuous stimuli are pathologically amplified. The pain is an expression of maladaptive plasticity within the nociceptive system, a series of changes that constitute a neural disease state. Multiple alterations distributed widely across the nervous system contribute to complex pain phenotypes. These alterations include ectopic generation of action potentials, facilitation and disinhibition of synaptic transmission, loss of synaptic connectivity and formation of new synaptic circuits, and neuroimmune interactions. Although neural lesions are necessary, they are not sufficient to generate neuropathic pain; genetic polymorphisms, gender, and age all influence the risk of developing persistent pain. Treatment needs to move from merely suppressing symptoms to a disease-modifying strategy aimed at both preventing maladaptive plasticity and reducing intrinsic risk.
登录
查看更多内容
影响因子：
9.8
作者：
Chizh, B. A.;Goehring, M.;Koppert, W.
通讯作者：
Koppert, W.
影响因子：
14.5
作者：
Bostock, H;Campero, M;Ochoa, JL
通讯作者：
Ochoa, JL
影响因子：
3.5
作者：
Baba, H;Ji, RR;Woolf, CJ
通讯作者：
Woolf, CJ
影响因子：
5.3
作者：
Amir, R;Kocsis, JD;Devor, M
通讯作者：
Devor, M
影响因子：
7.4
作者：
BENNETT, GJ;XIE, YK
通讯作者：
XIE, YK