Associations Between C-Reactive Protein, Insulin Sensitivity, and Resting Metabolic Rate in Adults: A Mediator Analysis.
Associations Between C-Reactive Protein, Insulin Sensitivity, and Resting Metabolic Rate in Adults: A Mediator Analysis.
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DOI：
10.3389/fendo.2018.00556
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发表时间：
2018
影响因子：
5.2
通讯作者：
Hauner H
中科院分区：
文献类型：
--
作者：
Drabsch T;Holzapfel C;Stecher L;Petzold J;Skurk T;Hauner H
目的：长期的正能量平衡促进肥胖的发展，肥胖是2型糖尿病（T2 DM）的主要危险因素。虽然先前已显示静息代谢率（RMR）增加与胰岛素敏感性（IS）之间存在相关性，但其潜在机制仍不清楚。介质分析的目的是研究炎症在RMR和IS之间的关联中的作用。方法：根据标准操作程序收集人体测量、临床和生活方式数据。使用间接量热法测量RMR。胰岛素抵抗的稳态模型评估（HOMA-IR）被用作IS参数，C反应蛋白（CRP）被测量以代表炎症状态。使用SPSS进行统计分析。结果：分析纳入了782名成人（517名女性），平均年龄为32.4 ± 12.0岁，平均体重指数（BMI）为24.6 ± 5.2 kg/m2。回归分析表明，在调整了无脂肪质量、性别、年龄和研究中心后，RMR和HOMA-IR（RR = 39.3 ± 7.3 kcal/d; p ≤ 0.001）以及CRP和HOMA-IR（RR = 0.5 ± 0.1; p ≤ 0.001）之间存在显著相关性。中介分析的结果不支持CRP是RMR和HOMA-IR之间关联的中介的假设。这些结果在参与者根据性别或BMI分层后没有改变。结论：在一个大的队列研究中，RMR和IS之间存在显著的相关性。然而，通过CRP水平确定的炎症状态不是这种关联中的介质。
Objective: Long-term positive energy balance promotes the development of obesity, a main risk factor for type 2 diabetes mellitus (T2DM). While an association between increased resting metabolic rate (RMR) and insulin sensitivity (IS) was shown previously, the underlying mechanisms remain unclear. Aim of the mediator analysis was to investigate the role of inflammation within the association between RMR and IS. Methods: Anthropometric, clinical, and lifestyle data were collected according to standard operating procedures. RMR was measured using indirect calorimetry. Homeostasis model assessment for insulin resistance (HOMA-IR) was used as an IS parameter and C-reactive protein (CRP) was measured to represent the inflammatory status. Statistical analyses were performed using SPSS. Results: The analysis included 782 adults (517 females) with a mean age of 32.4 ± 12.0 years and a mean body mass index (BMI) of 24.6 ± 5.2 kg/m2. Regression analysis indicated a significant evidence for associations between RMR and HOMA-IR (ß = 39.3 ± 7.3 kcal/d; p ≤ 0.001) and CRP and HOMA-IR (ß = 0.5 ± 0.1; p ≤ 0.001) after adjustment for fat-free mass, sex, age, and study site. Results of the mediator analysis did not support the hypothesis that CRP is a mediator for the association between RMR and HOMA-IR. These results did not change after participant stratification according to sex or BMI. Conclusion: A significant evidence for an association between RMR and IS was shown in a large cohort. However, the inflammatory status, determined via CRP levels, was not a mediator within this association.
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影响因子：
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