A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form.
A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form.
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头部激活剂结合蛋白以可溶性和膜锚定的形式存在于水螅中。
作者：
W. Hampe;J. Urny;I. Franke;S. Hoffmeister;D. Herrmann;C. Petersen;J. Lohmann;H. Schaller
神经肽头激活因子在水螅干细胞的增殖和分化中起着重要作用。通过亲和层析，从绿水藻的多头突变体中分离出一种200 kDa的头部激活剂结合蛋白（HAB）。部分氨基酸序列被用来克隆的HAB cDNA编码的受体与一个独特的对齐的胞外模块，跨膜结构域，和一个短的羧基端的胞质尾。具有这些模块的相同对齐的哺乳动物HAB同源物在脑发育早期表达。特异性抗体揭示了HAB在水螅中作为跨膜受体的存在，但也作为分泌蛋白，两者都能够结合头部激活剂。HAB在再生过程中的分泌和在高决定电位区域的表达暗示HAB在调节头部激活剂的作用浓度和范围中的作用。
The neuropeptide head activator plays an important role for proliferation and determination of stem cells in hydra. By affinity chromatography a 200 kDa head-activator binding protein, HAB, was isolated from the multiheaded mutant of Chlorohydra viridissima. Partial amino acid sequences were used to clone the HAB cDNA which coded for a receptor with a unique alignment of extracellular modules, a transmembrane domain, and a short carboxy-terminal cytoplasmic tail. A mammalian HAB homologue with identical alignment of these modules is expressed early in brain development. Specific antibodies revealed the presence of HAB in hydra as a transmembrane receptor, but also as secreted protein, both capable of binding head activator. Secretion of HAB during regeneration and expression in regions of high determination potential hint at a role for HAB in regulating the concentration and range of action of head activator.
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影响因子：
19
作者：
Molloy, SS;Anderson, ED;Thomas, G
通讯作者：
Thomas, G
新型信号肽 pedibin 和 Hym-346 降低了位置值，从而增强了水螅的足部形成。
DOI：
10.1242/dev.126.3.517
发表时间：
1999
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Grens,A;Shimizu,H;Hoffmeister,SA;Bode,HR;Fujisawa,T
通讯作者：
Fujisawa,T
影响因子：
10.5
作者：
SHEETS, MD;FOX, CA;WICKENS, M
通讯作者：
WICKENS, M
影响因子：
3.7
作者：
J. Gliemann
通讯作者：
J. Gliemann
DOI：
10.1073/pnas.91.19.9170
发表时间：
1994-09-13
影响因子：
11.1
作者：
HANNEKEN, A;YING, WB;BAIRD, A
通讯作者：
BAIRD, A