Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant.
Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant.
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DOI：
10.1111/j.1528-1167.2010.02731.x
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发表时间：
2011-01
期刊：
影响因子：
5.6
通讯作者：
Kaila K
中科院分区：
文献类型：
--
作者：
Tolner EA;Hochman DW;Hassinen P;Otáhal J;Gaily E;Haglund MM;Kubová H;Schuchmann S;Vanhatalo S;Kaila K
CO2 has been long recognized for its anticonvulsant properties. We aimed to determine whether inhaling 5% CO2 can be used to suppress seizures in epilepsy patients. The effect of CO2 on cortical epileptic activity accompanying behavioral seizures was studied in rats and a non-human primate and based on these data, preliminary tests were carried out in humans. In freely moving rats, cortical afterdischarges paralleled by myoclonic convulsions were evoked by sensorimotor cortex stimulation. 5% CO2 was applied for 5 minutes, 3 minutes before stimulation. In macaque monkeys, hypercarbia was induced by hypoventilation while seizure activity was electrically or chemically evoked in the sensorimotor cortex. Seven patients with drug-resistant partial epilepsy were examined with video-EEG and received 5% CO2 in medical carbogen shortly after electrographic seizure onset. In rats, 5% CO2 strongly suppressed cortical afterdischarges, by ca. 75%, while responses to single-pulse stimulation were reduced by about 15% only. In macaques, increasing pCO2 from 37 to 44-45 mmHg (corresponding to inhalation of 5% CO2 or less) suppressed stimulation-induced cortical afterdischarges by about 70% and single, bicuculline-induced epileptiform spikes by ca. 25%. In a pilot trial carried out in 7 patients, a rapid termination of electrographic seizures was seen despite the fact that the application of 5% CO2 was started after seizure generalization. 5% CO2 has a fast and potent anticonvulsant action. The present data suggest that medical carbogen with 5% CO2 can be used for acute treatment to suppress seizures in epilepsy patients.
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影响因子：
11.2
作者：
Helmy, Mohamed M.;Tolner, Else A.;Kaila, Kai
通讯作者：
Kaila, Kai
影响因子：
5.6
作者：
Doherty, Michael J.;Youn, Clover;Haltiner, Alan M.
通讯作者：
Haltiner, Alan M.
影响因子：
2.5
作者：
Haglund, MM;Hochman, DW
通讯作者：
Hochman, DW
影响因子：
3.7
作者：
Griez, Eric J.;Colasanti, Alessandro;van Diest, Rob;Salamon, Ewa;Schruers, Koen
通讯作者：
Schruers, Koen
影响因子：
2.5
作者：
Dulla, Chris G.;Frenguelli, Bruno G.;Masino, Susan A.
通讯作者：
Masino, Susan A.