Pathophysiological mechanisms of root resorption after dental trauma: a systematic scoping review.
Pathophysiological mechanisms of root resorption after dental trauma: a systematic scoping review.
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DOI：
10.1186/s12903-021-01510-6
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发表时间：
2021-03-26
期刊：
影响因子：
2.9
通讯作者：
Knüttel H
中科院分区：
文献类型：
--
作者：
Galler KM;Grätz EM;Widbiller M;Buchalla W;Knüttel H
本范围审查的目的是系统地探讨目前的知识驱动和控制创伤相关的根吸收的细胞和分子过程，以确定研究差距，并提供一个基础，以改善预防和治疗。根据研究问题检索了截至2021年2月的四个主要书目数据库，并手动补充。包括牙外伤后牙根吸收的生理学、组织学、解剖学和临床方面的报告。删除重复内容，通过标题/摘要筛选收集的材料，并基于全文评估合格性。对相关方面进行了摘录、整理和总结。846篇论文被确定为与定性总结相关。文献中关于创伤相关牙根吸收的病理生理机制的研究很少。尽管某些形式的吸收已经被彻底探索，但其他形式的吸收，特别是侵入性宫颈吸收的病因仍在争论中，导致诊断不足和临床建议不一致。进行性替代吸收的有效疗法尚未确立。尽管RANKL/RANK/OPG系统的发现对于我们理解骨吸收过程至关重要，但有关破骨细胞/破牙细胞功能调节的许多问题仍未得到解答。该范围审查提供了现有证据的概述，但也确定了需要通过持续的实验室和临床研究来解决的知识差距。在线版本包含补充材料，可通过10.1186/s12903-021-01510-6获得。
The objective of this scoping review was to systematically explore the current knowledge of cellular and molecular processes that drive and control trauma-associated root resorption, to identify research gaps and to provide a basis for improved prevention and therapy. Four major bibliographic databases were searched according to the research question up to February 2021 and supplemented manually. Reports on physiologic, histologic, anatomic and clinical aspects of root resorption following dental trauma were included. Duplicates were removed, the collected material was screened by title/abstract and assessed for eligibility based on the full text. Relevant aspects were extracted, organized and summarized. 846 papers were identified as relevant for a qualitative summary. Consideration of pathophysiological mechanisms concerning trauma-related root resorption in the literature is sparse. Whereas some forms of resorption have been explored thoroughly, the etiology of others, particularly invasive cervical resorption, is still under debate, resulting in inadequate diagnostics and heterogeneous clinical recommendations. Effective therapies for progressive replacement resorptions have not been established. Whereas the discovery of the RANKL/RANK/OPG system is essential to our understanding of resorptive processes, many questions regarding the functional regulation of osteo-/odontoclasts remain unanswered. This scoping review provides an overview of existing evidence, but also identifies knowledge gaps that need to be addressed by continued laboratory and clinical research. The online version contains supplementary material available at 10.1186/s12903-021-01510-6.
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DOI：
10.1084/jem.190.12.1741
发表时间：
1999-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Arai F;Miyamoto T;Ohneda O;Inada T;Sudo T;Brasel K;Miyata T;Anderson DM;Suda T
通讯作者：
Suda T
影响因子：
0.9
作者：
Babaji P;Devanna R;Jagtap K;Chaurasia VR;Jerry JJ;Choudhury BK;Duhan D
通讯作者：
Duhan D
影响因子：
4.4
作者：
Armstrong, Rebecca;Hall, Belinda J.;Waters, Elizabeth
通讯作者：
Waters, Elizabeth
影响因子：
56.9
作者：
BLAIR, HC;TEITELBAUM, SL;GLUCK, S
通讯作者：
GLUCK, S
DOI：
10.1016/s0300-9785(81)80008-7
发表时间：
1981-01-01
期刊：
INTERNATIONAL JOURNAL OF ORAL SURGERY
影响因子：
--
作者：
ANDREASEN, JO
通讯作者：
ANDREASEN, JO