Structural characterization of the mitochondrial Ca(2+) uniporter provides insights into Ca(2+) uptake and regulation.
Structural characterization of the mitochondrial Ca(2+) uniporter provides insights into Ca(2+) uptake and regulation.
复制标题
线粒体 Ca2 单向转运蛋白的结构表征提供了对 Ca2 摄取和调节的见解
DOI：
10.1016/j.isci.2021.102895
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发表时间：
2021-08-20
期刊：
影响因子：
5.8
通讯作者：
Jia Z
中科院分区：
文献类型：
--
作者：
Wu W;Zheng J;Jia Z
线粒体单向转运体是线粒体内膜中的Ca2+选择性离子传导通道，参与各种细胞过程。这种单向转运蛋白的组分，包括成孔膜亚基MCU和调节亚基MCUB、EMRE、MICU 1和MICU 2，近年来已被鉴定。以前，广泛的研究揭示了单向转运体活动的各个方面，并提出了线粒体Ca 2+摄取的多种调控模型。最近，单个辅助组件的uniporter和它的holocomplex已在结构上的特点，提供了第一个洞察组件的结构和它们的空间关系的上下文中的uniporter。在这里，我们回顾了最近的单向转运蛋白结构的研究，试图建立一个架构框架，阐明机制，管理线粒体Ca2+的摄取和调节，并解决一些明显的争议。这些信息可以促进线粒体Ca2+渗透的进一步表征，并更好地理解uniporter相关的疾病状况。单向转运体含有多个亚基，调节细胞的各种过程。单向转运体的全复合体结构研究取得了重大进展。
The mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane that is involved in various cellular processes. The components of this uniporter, including the pore-forming membrane subunit MCU and the modulatory subunits MCUb, EMRE, MICU1, and MICU2, have been identified in recent years. Previously, extensive studies revealed various aspects of uniporter activities and proposed multiple regulatory models of mitochondrial Ca2+ uptake. Recently, the individual auxiliary components of the uniporter and its holocomplex have been structurally characterized, providing the first insight into the component structures and their spatial relationship within the context of the uniporter. Here, we review recent uniporter structural studies in an attempt to establish an architectural framework, elucidating the mechanism that governs mitochondrial Ca2+ uptake and regulation, and to address some apparent controversies. This information could facilitate further characterization of mitochondrial Ca2+ permeation and a better understanding of uniporter-related disease conditions. The uniporter contains multiple subunits regulating various cellular processes Significant structural progresses have been made for the holo-complex of uniporter The holo-complex structures have inspired to propose several regulatory models Ion; Molecular biology; Membranes;
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影响因子：
16
作者：
Dong Z;Shanmughapriya S;Tomar D;Siddiqui N;Lynch S;Nemani N;Breves SL;Zhang X;Tripathi A;Palaniappan P;Riitano MF;Worth AM;Seelam A;Carvalho E;Subbiah R;Jaña F;Soboloff J;Peng Y;Cheung JY;Joseph SK;Caplan J;Rajan S;Stathopulos PB;Madesh M
通讯作者：
Madesh M
线粒体钙单向转运蛋白双环离子选择性过滤器的离子和抑制剂结合。
DOI：
10.1073/pnas.1620316114
发表时间：
2017-04-04
影响因子：
11.1
作者：
Cao, Chan;Wang, Shuqing;Chou, James J.
通讯作者：
Chou, James J.
DOI：
10.1111/j.1460-9568.2010.07576.x
发表时间：
2011-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Barsukova A;Komarov A;Hajnóczky G;Bernardi P;Bourdette D;Forte M
通讯作者：
Forte M
DOI：
10.1126/science.1214977
发表时间：
2012-05-18
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Bick AG;Calvo SE;Mootha VK
通讯作者：
Mootha VK
影响因子：
1.5
作者：
Docampo R;Vercesi AE;Huang G
通讯作者：
Huang G