Outsmarting a mastermind.

Outsmarting a mastermind.
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DOI:
10.1016/j.devcel.2009.12.002
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发表时间:
2009-12
期刊:
影响因子:
11.8
通讯作者:
Jones KA
Jones KA
中科院分区:
生物学1区
文献类型:
--
作者:
Jones KA

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Moellering et al. recently reported that a cell-permeable “stapled” synthetic peptide of the Notch coactivator Mastermind is a potent dominant-negative inhibitor of oncogenic Notch signaling in T cell acute lymphoblastic leukemia. This new class of inhibitor may find broad utility in blocking protein-protein interactions that underlie many human diseases.
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