Enhanced Cholesteryl Ester Transfer Protein Activities and Abnormalities of High Density Lipoproteins in Familial Hypercholesterolemia
Enhanced Cholesteryl Ester Transfer Protein Activities and Abnormalities of High Density Lipoproteins in Familial Hypercholesterolemia
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家族性高胆固醇血症中胆固醇酯转移蛋白活性增强和高密度脂蛋白异常
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
R. Takeda
中科院分区：
文献类型：
--
作者：
Akihiro Inazu;J. Koizumi;H. Mabuchi;K. Kajinami;R. Takeda
胆固醇酯转运蛋白可能在高密度脂蛋白（HDL）和含载脂蛋白B的脂蛋白之间的胆固醇酯代谢中发挥作用。为探讨高密度脂蛋白（HDL）与胆固醇酯转运蛋白（CETP）活性在动脉粥样硬化发生发展中的关系，本研究对家族性高胆固醇血症（GH）患者CETP活性进行了检测。杂合子FH组HDL-C及HDL-C/apo A-I质量比低于正常对照组。与血脂正常对照组相比，孵育FH血清中的总CETP活性增加了2倍。通过测量放射性胆固醇酯从HDL（1.125小于d小于1.21 μ g/ml）到LDL（1.019小于d小于1.060 μ g/ml）的转移来进行脂蛋白缺乏血清（d大于1.215 μ g/ml）中CETP活性的测定。杂合子FH的CETP活性（79 +/- 4 nmol/ml/h）显著高于正常血脂对照组（54 +/- 6 nmol/ml/h）。总胆固醇酯转移的增加主要是由于在大于1.215 μ g/ml时CETP活性增加，可能反映了血清中CETP质量的增加。当胆固醇浓度大于1.215 μ g/ml时，CETP活性升高与HDL-胆固醇/甘油三酯质量比呈正相关（r = 0.496，p <0.01），与HDL-胆固醇/apoA-I质量比呈负相关（r =-0.334，p <0.05）。这些结果表明，增强CETP活动可能有助于增加风险的发展动脉粥样硬化FH改变胆固醇酯在血清脂蛋白的分布。
Cholesteryl ester transfer protein may play a role in the cholesteryl ester metabolism between high density lipoproteins (HDL) and apolipoprotein B-containing lipoproteins. To investigate relationship between HDL and cholesteryl ester transfer protein (CETP) activity in the development of atherosclerosis, the present study has focused on CETP activity in the patients with familial hypercholesterolemia (GH). HDL-C and HDL-C/apo A-I mass ratio in heterozygous FH were lower than those in normolipidemic controls. There was a 2-fold increase in total CETP activity in incubated FH serum compared with normolipidemic controls. Assays for CETP activity in the lipoprotein deficient serum (d greater than 1.215 g/ml) were carried out by measuring the transfer of radioactive cholesteryl ester from HDL (1.125 less than d less than 1.21 g/ml) to LDL (1.019 less than d less than 1.060 g/ml). CETP activities in heterozygous FH (79 +/- 4 nmol/ml/h) was significantly higher than those in normolipidemic controls (54 +/- 6 nmol/ml/h). The increased total cholesteryl ester transfer mainly results from increased CETP activity in the d greater than 1.215 g/ml, possibly reflecting an increase in CETP mass in serum. Increased CETP activity in the d greater than 1.215 g/ml was correlated positively with IDL-cholesterol/triglyceride mass ratio (r = 0.496, p less than 0.01), and negatively with HDL-cholesterol/apo A-I mass ratio (r = -0.334, p less than 0.05). These results indicate that the enhanced CETP activities may contribute to increase risk for developing atherosclerosis in FH by changing the distribution of cholesteryl ester in serum lipoproteins.
致动脉粥样硬化饮食会增加兔肝脏中胆固醇酯转移蛋白信使 RNA 的水平。
DOI：
10.1172/jci114446
发表时间：
1990
期刊：
The Journal of clinical investigation
影响因子：
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作者：
Quinet,EM;Agellon,LB;Kroon,PA;Marcel,YL;Lee,YC;Whitlock,ME;Tall,AR
通讯作者：
Tall,AR
影响因子：
15.9
作者：
FIELDING, PE;FIELDING, CJ;TUN, P
通讯作者：
TUN, P
加速胆固醇酯在血脂异常血浆中的转移。
DOI：
10.1172/jci112940
发表时间：
1987
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Tall,A;Granot,E;Brocia,R;Tabas,I;Hesler,C;Williams,K;Denke,M
通讯作者：
Denke,M