Role of inflammation and its mediators in acute ischemic stroke.
Role of inflammation and its mediators in acute ischemic stroke.
复制标题
DOI：
10.1007/s12265-013-9508-6
复制
发表时间：
2013-10
影响因子：
3.4
通讯作者：
Li, Guohong
中科院分区：
文献类型：
--
作者：
Jin, Rong;Liu, Lin;Zhang, Shihao;Nanda, Anil;Li, Guohong
炎症在缺血性脑卒中和其他形式的缺血性脑损伤的发病机制中起着重要作用。越来越多的证据表明，炎症反应是一把双刃剑，它不仅加剧了脑卒中急性期的继发性脑损伤，而且有利于脑卒中后的脑恢复。本文就炎症及其介质在急性缺血性脑卒中中的作用作一综述。我们讨论了缺血性脑卒中后不同阶段的各种促炎和抗炎反应及其在临床试验中失败的可能原因。毫无疑问，为了将有希望的临床前发现转化为临床实践，还有很多工作要做。更好地了解促炎和抗炎反应之间的动态平衡，识别临床前研究和临床试验之间的差异，可能为设计有效的治疗方法提供基础。
Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms of ischemic brain injury. Increasing evidence suggests that inflammatory response is a double-edged sword, as it not only exacerbates secondary brain injury in the acute stage of stroke but also beneficially contributes to brain recovery after stroke. In this article, we provide an overview on the role of inflammation and its mediators in acute ischemic stroke. We discuss various pro-inflammatory and anti-inflammatory responses in different phases after ischemic stroke and the possible reasons for their failures in clinical trials. Undoubtedly, there is still much to be done in order to translate promising pre-clinical findings into clinical practice. A better understanding of the dynamic balance between pro- and anti-inflammatory responses and identifying the discrepancies between pre-clinical studies and clinical trials may serve as a basis for designing effective therapies.
登录
查看更多内容
影响因子：
6.3
作者：
Basu, A;Lazovic, J;Levison, SW
通讯作者：
Levison, SW
DOI：
10.1073/pnas.96.22.12866
发表时间：
1999-10-26
影响因子：
11.1
作者：
Alessandrini, A;Namura, S;Bonventre, JV
通讯作者：
Bonventre, JV
影响因子：
37.8
作者：
Caso, Javier R.;Pradillo, Jesus M.;Lizasoain, Ignacio
通讯作者：
Lizasoain, Ignacio
影响因子：
4.5
作者：
Cha JK;Jeong MH;Kim EK;Lim YJ;Ha BR;Kim SH;Kim JW
通讯作者：
Kim JW
影响因子：
6.2
作者：
Bsibsi, M;Persoon-Deen, C;Van Noort, JM
通讯作者：
Van Noort, JM