Surface expression of P-selectin on platelets is related with clinical worsening in acute ischemic stroke.
Surface expression of P-selectin on platelets is related with clinical worsening in acute ischemic stroke.
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DOI：
10.3346/jkms.2002.17.6.811
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发表时间：
2002-12
影响因子：
4.5
通讯作者：
Kim JW
中科院分区：
文献类型：
--
作者：
Cha JK;Jeong MH;Kim EK;Lim YJ;Ha BR;Kim SH;Kim JW
血小板活化在动脉疾病中起着至关重要的作用。在这项研究中，我们发现血小板上 P-选择素表达的上调与急性缺血性中风的临床恶化有关。我们连续（24小时内、72小时内和7天内）测量了急性缺血性中风患者（n=45）血小板上P-选择素的表达，并研究了其程度与缺血性中风临床严重程度之间的相关性。在缺血性中风发作后 72 小时和 7 天观察到 P-选择素表达与美国国立卫生研究院中风量表 (NIHSS) 之间存在显着相关性。与未恶化的患者相比，临床恶化的患者血小板上 P-选择素的表达显着增加。这些结果表明血小板上的P-选择素表达可能导致急性缺血性卒中临床病程的加重。因此，充分控制活化的血小板是急性缺血性中风的重要治疗策略。
Platelet activation has a critical role in arterial disorders. In this study, we showed that the upregulation of P-selectin expression on platelets was related with clinical worsening in acute ischemic stroke. We serially (within 24 hr, at 72 hr, and 7 days) measured the expression of P-selectin on platelets in patients with acute ischemic stroke (n=45) and investigated the correlation between their extents and clinical severity of ischemic stroke. A significant relationship between the P-selectin expressions and National Institute of Health Stroke Scale (NIHSS) was observed at 72 hr and 7 days after ischemic stroke onset. Patients with clinical deterioration showed significantly increased expression of P-selectin on platelets as compared to those without deterioration. These results suggest that the P-selectin expression on platelets may contribute to the aggravation of clinical course in acute ischemic stroke. Thus, adequate manipulation of activated platelets is an important therapeutic strategy in acute ischemic stroke.
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