A computer based model for realistic simulations of neural networks
A computer based model for realistic simulations of neural networks
复制标题
用于神经网络真实模拟的计算机模型
作者：
Örjan Ekeberg;P. Wallén;A. Lansner;H. Tråvén;L. Brodin;S. Grillner
计算机模拟作为神经生理学工具的使用为理解复杂系统和测试给定模型是否可以解释实验结果创造了新的可能性。然而，模拟需要模型的详细说明，包括神经细胞动作电位和突触传递。我们描述了一个中等复杂性的神经元模型，用少量的隔间代表的索马和树突树，并配备了Na+，K+，Ca2+，和Ca2+依赖的K+通道。电导的变化，在不同的车厢被用来模拟传统的兴奋性和抑制性突触的相互作用。电压依赖性NMDA受体通道也包括在内，并且影响电导和Ca2+离子的流入。这个神经元模型已经被设计用于神经网络的分析，特别是用于模拟在简单的脊椎动物七鳃鳗中产生运动的网络。通过将实验建立的属性分配给模拟细胞及其突触，可以验证这些属性是否足以解释网络运行中的许多实验发现。然而，该模型是足够普遍的，是有用的现实模拟，也为其他神经系统。
The use of computer simulations as a neurophysiological tool creates new possibilities to understand complex systems and to test whether a given model can explain experimental findings. Simulations, however, require a detailed specification of the model, including the nerve cell action potential and synaptic transmission. We describe a neuron model of intermediate complexity, with a small number of compartments representing the soma and the dendritic tree, and equipped with Na+, K+, Ca2+, and Ca2+ dependent K+ channels. Conductance changes in the different compartments are used to model conventional excitatory and inhibitory synaptic interactions. Voltage dependent NMDA-receptor channels are also included, and influence both the electrical conductance and the inflow of Ca2+ ions. This neuron model has been designed for the analysis of neural networks and specifically for the simulation of the network generating locomotion in a simple vertebrate, the lamprey. By assigning experimentally established properties to the simulated cells and their synapses, it has been possible to verify the sufficiency of these properties to account for a number of experimental findings of the network in operation. The model is, however, sufficiently general to be useful for realistic simulation also of other neural systems.
影响因子：
56.9
作者：
BUCHANAN, JT;GRILLNER, S
通讯作者：
GRILLNER, S