Regulation of Early Human Growth: Impact on Long-Term Health
Regulation of Early Human Growth: Impact on Long-Term Health
复制标题
人类早期生长的调节：对长期健康的影响
DOI：
--
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发表时间：
2014
影响因子：
3.9
通讯作者：
Martina Weber
中科院分区：
文献类型：
--
作者：
B. Koletzko;M. Chourdakis;V. Grote;C. Hellmuth;C. Prell;P. Rzehak;O. Uhl;Martina Weber
成长和发展是童年的主要特征。偏离正常生长可能表明存在严重的健康挑战。早期发育迟缓和营养不良对后来健康的不利影响早已为人所知。相比之下，早期体重和体脂的快速增加对规划后期疾病风险的影响直到最近才得到越来越多的关注。许多观察性研究将儿童早期饮食和早期快速生长与日后肥胖和相关疾病的风险联系起来。因果关系在一项大型双盲随机试验中得到证实，该试验检验了“早期蛋白质假说”。在这项试验中，我们发现，婴儿期蛋白质供应的减少使早期生长正常化，并显着降低了早期学龄儿童的肥胖率。这些结果表明，需要更详细地描述和分析增长模式及其通过饮食的调节，并描述潜在的代谢和表观遗传机制，因为这可能与公共卫生和政策有关。更好地了解增长模式及其调控，对于促进公共健康、以消费者为导向的营养建议以及为特定目标人群开发改进的食品可能有重大好处。
Growth and development are central characteristics of childhood. Deviations from normal growth can indicate serious health challenges. The adverse impact of early growth faltering and malnutrition on later health has long been known. In contrast, the impact of rapid early weight and body fat gain on programming of later disease risk have only recently received increased attention. Numerous observational studies related diet in early childhood and rapid early growth to the risk of later obesity and associated disorders. Causality was confirmed in a large, double-blind randomised trial testing the ‘Early Protein Hypothesis'. In this trial we found that attenuation of protein supply in infancy normalized early growth and markedly reduced obesity prevalence in early school age. These results indicate the need to describe and analyse growth patterns and their regulation through diet in more detail and to characterize the underlying metabolic and epigenetic mechanisms, given the potential major relevance for public health and policy. Better understanding of growth patterns and their regulation could have major benefits for the promotion of public health, consumer-orientated nutrition recommendations, and the development of improved food products for specific target populations.
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影响因子：
9.3
作者：
Lutter, Chessa K.;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
基因表达的表观遗传变化：关注“肝脏X受体基因启动子在产前蛋白质限制的小鼠模型中高度甲基化”。
DOI：
10.1152/ajpregu.00760.2009
发表时间：
2010
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Alexander,BarbaraT
通讯作者：
Alexander,BarbaraT
影响因子：
3.5
作者：
Waterland, Robert A.;Kellermayer, Richard;Shen, Lanlan
通讯作者：
Shen, Lanlan
影响因子：
5.8
作者：
Chernausek, Steven D.
通讯作者：
Chernausek, Steven D.
影响因子：
9.8
作者：
KETELSLEGERS, JM;MAITER, D;THISSEN, JP
通讯作者：
THISSEN, JP