A facile strategy toward hierarchically porous composite scaffold for osteosarcoma ablation and massive bone defect repair
A facile strategy toward hierarchically porous composite scaffold for osteosarcoma ablation and massive bone defect repair
复制标题
用于骨肉瘤消融和大面积骨缺损修复的分层多孔复合支架的简便策略
DOI：
10.1016/j.compositesb.2022.109660
复制
发表时间：
2022-01
影响因子：
13.1
通讯作者：
Zongke Zhou
中科院分区：
文献类型：
--
作者：
Tingxian Ling;XiangJun Zha;Kai Zhou;Xing Zhao;Jin Jia;Kaiqi Pan;Anjing Chen;Weizhong Yang;Zongke Zhou
骨肉瘤的外科治疗因其巨大的骨缺损和肿瘤复发而仍是一个挑战。在此，一个简单的策略启发烹饪发展到制造分级多孔复合支架的骨肿瘤消融和大块骨缺损修复。丝素蛋白作为生物发泡剂，通过与二维Ti 3C 2 MXene纳米片的强相互作用，在机械搅拌下发泡形成物理水凝胶。细菌纤维素（BC）用于稳定气泡以保持多孔结构。采用冷冻干燥法制备了SF/BC/MXene（FSCM）多孔支架材料，其大孔直径约为200 μm，壁为纳米纤维状。这种FSCM复合支架在近红外（NIR）光照射后表现出突出的骨肉瘤消融性能，并具有良好的骨缺损修复能力。本研究为构建具有分级多孔结构的双功能支架材料提供了一种新的思路，可用于骨肉瘤的临床治疗，促进骨肿瘤的消融和大面积骨缺损的修复。蛋白质发泡是制备多功能骨组织工程复合支架的有效方法。· MXene赋予FSCM支架优异的骨肉瘤消融性能。·分级多孔生物质支架表现出突出的骨缺损修复能力。多功能生物质复合支架在骨肉瘤的临床治疗中显示出巨大的前景。
The surgical treatment of osteosarcoma remains a challenge because of massive bone defects and tumor recurrence. Herein, a facile strategy inspired by cooking is developed to fabricate hierarchically porous composite scaffold for bone tumor ablation and massive bone defect repair. Silk fibroin (SF) as a biological foaming agent is foamed by mechanical stirring to form physical hydrogel through strong interaction with 2D Ti 3 C 2 MXene nanosheets . Bacterial cellulose (BC) is used to stabilize air bubbles to keep porous structure . Hierarchically porous SF/BC/MXene (FSCM) scaffold with ∼200 μm macropore and nanofibrillar wall is acquired by lyophilization. Such FSCM composite scaffold presents prominent osteosarcoma ablation performance after near-infrared (NIR) light irradiation, and features excellent bone defect repair ability. This work represents a newly strategy to fabricate hierarchically porous bifunctional scaffold for enhancing bone tumor ablation and facilitating massive bone defect repair in the clinical treatment of osteosarcoma. • Protein foaming is a valid strategy for fabricating multifunctional bone tissue engineering composite scaffold. • MXene endowed FSCM scaffold with excellent osteosarcoma ablation performance. • Hierarchically porous bio-mass scaffold presented prominent bone defect repair capability. • Multifunctional bio-mass composite scaffold showed great prospect for the clinical treatment of osteosarcoma.
登录
查看更多内容
影响因子：
29.4
作者：
Bowen Yang;J. Yin;Yu Chen;Shanshan Pan;Heliang Yao;Youshui Gao;Jianlin Shi
通讯作者：
Bowen Yang;J. Yin;Yu Chen;Shanshan Pan;Heliang Yao;Youshui Gao;Jianlin Shi
影响因子：
9.5
作者：
Jie Yin;Qiuyang Han;Junchuan Zhang;Yunxiu Liu;Xueqi Gan;K. Xie;L. Xie;Yi Deng
通讯作者：
Jie Yin;Qiuyang Han;Junchuan Zhang;Yunxiu Liu;Xueqi Gan;K. Xie;L. Xie;Yi Deng
影响因子：
2
作者：
M. Mison;L. Duda
通讯作者：
M. Mison;L. Duda
影响因子：
--
作者：
Moore, Drew D;Luu, Hue H
通讯作者：
Luu, Hue H
DOI：
10.1200/jco.2002.20.3.776
发表时间：
2002-02
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
S. Bielack;B. Kempf‐Bielack;G. Delling;G. Exner;S. Flege;K. Helmke;R. Kotz;M. Salzer‐Kuntschik-M.-Salzer‐Kuntschi
通讯作者：
S. Bielack;B. Kempf‐Bielack;G. Delling;G. Exner;S. Flege;K. Helmke;R. Kotz;M. Salzer‐Kuntschik-M.-Salzer‐Kuntschi