The prevalence of Helicobacter pylori infection and other risk factors among Mongolian dyspeptic patients who have a high incidence and mortality rate of gastric cancer.
The prevalence of Helicobacter pylori infection and other risk factors among Mongolian dyspeptic patients who have a high incidence and mortality rate of gastric cancer.
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DOI：
10.1186/s13099-018-0240-2
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发表时间：
2018
期刊：
影响因子：
4.2
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Khasag O;Boldbaatar G;Tegshee T;Duger D;Dashdorj A;Uchida T;Matsuhisa T;Yamaoka Y
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Mongolia has not only the second highest incidence rate but also the highest mortality rate for gastric cancer globally. In addition to gastric cancer, ulcerative disease complications are also life threatening; thus, investigating Helicobacter pylori infection and other risk factors is essential. H.pylori infection was high in tested dyspeptic patients from all parts of Mongolia, with an overall infection rate of 80.0%. Logistic regression analysis showed that H. pylori infection was associated with gastritis (odds ratio; 9.0 ([95% confidence interval 5.0–16.2]); p < 0.0001). H. pylori infection (3.3 [2.0–5.4]; p < 0.0001) and > 40 years old (1.5 [1.0–2.0]; p < 0.02) were both associated with atrophy. However, > 40 years old (3.8 [2.4–6.0]; p < 0.0001) and high salt intakes (1.6 [1.0–2.3]; p < 0.02), but not H. pylori infection, were associated with intestinal metaplasia. Excessive amount of salt usage was dramatically higher in northern and western parts of Mongolia, where precancerous diseases, such as erosive esophagitis (for cardia cancer), severe atrophy, and intestinal metaplasia (for non-cardia cancer), were highly prevalent. H. pylori infection was the major gastric health problem among the Mongolian population. In addition, environmental factors such as high salt intake worsened the clinical outcome. Therefore, a nationwide screening and eradication of H. pylori infection as well as salt-reducing measures should be implemented.
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DOI：
10.2741/3320
发表时间：
2009-01-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Mbulaiteye SM;Hisada M;El-Omar EM
通讯作者：
El-Omar EM
影响因子：
9.8
作者：
Correa, Pelayo;Piazuelo, M. Blanca;Wilson, Keith T.
通讯作者：
Wilson, Keith T.
影响因子：
2.5
作者：
Choi IJ
通讯作者：
Choi IJ
影响因子：
24.5
作者：
Lundell, LR;Dent, J;Wallin, L
通讯作者：
Wallin, L
影响因子：
24.5
作者：
Malfertheiner, P.;Megraud, F.;El-Omar, E. M.
通讯作者：
El-Omar, E. M.