Intrinsic brain connectivity related to age in young and middle aged adults.
Intrinsic brain connectivity related to age in young and middle aged adults.
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DOI：
10.1371/journal.pone.0044067
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Constable RT
中科院分区：
文献类型：
--
作者：
Hampson M;Tokoglu F;Shen X;Scheinost D;Papademetris X;Constable RT
从青年到中年，研究了人类大脑静息状态连接性中与睡眠相关的变化。一个基于体素的网络测量，程度，被用来评估整个大脑组织连接的年龄相关差异。随着年龄的增长，在大脑边缘皮层和皮层下区域的连接性增加。在皮层区域发现了连通性的下降，包括视觉区域和默认模式网络。这些发现不同于最近的发展研究，研究早期的生长轨迹，并与成熟衰老过程中认知功能和情感处理的已知变化相一致。这些结果支持并扩展了以前的研究结果，这些研究结果依赖于对感兴趣区域的先验定义进行分析。这种应用基于体素的测量来检查单个组织元素随时间的功能连接性的方法，而不需要先验的感兴趣区域定义，为脑科学提供了一个重要的新工具。
Age-related variations in resting state connectivity of the human brain were examined from young adulthood through middle age. A voxel-based network measure, degree, was used to assess age-related differences in tissue connectivity throughout the brain. Increases in connectivity with age were found in paralimbic cortical and subcortical regions. Decreases in connectivity were found in cortical regions, including visual areas and the default mode network. These findings differ from those of recent developmental studies examining earlier growth trajectories, and are consistent with known changes in cognitive function and emotional processing during mature aging. The results support and extend previous findings that relied on a priori definitions of regions of interest for their analyses. This approach of applying a voxel-based measure to examine the functional connectivity of individual tissue elements over time, without the need for a priori region of interest definitions, provides an important new tool in brain science.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
3.2
作者：
Grady, CL;Springer, MV;Winocur, G
通讯作者：
Winocur, G
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U
DOI：
10.1523/jneurosci.2308-09.2009
发表时间：
2009-12-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gong G;Rosa-Neto P;Carbonell F;Chen ZJ;He Y;Evans AC
通讯作者：
Evans AC