Quantitative assessment of pulmonary perfusion using dynamic contrast-enhanced CT in patients with chronic obstructive pulmonary disease: correlations with pulmonary function test and CT volumetric parameters
Quantitative assessment of pulmonary perfusion using dynamic contrast-enhanced CT in patients with chronic obstructive pulmonary disease: correlations with pulmonary function test and CT volumetric parameters
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使用动态增强CT定量评估慢性阻塞性肺疾病患者的肺灌注：与肺功能测试和CT容积参数的相关性
DOI：
10.1177/0284185114535208
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发表时间：
2015-05
期刊：
影响因子：
1.3
通讯作者：
Li Bing
中科院分区：
文献类型：
--
作者：
Guan Yu;Xia Yi;Fan Li;Liu Shi-yuan;Yu Hong;Li Bin;Zhao Li-ming;Li Bing
肺功能测试（PFT）通常用于帮助诊断慢性阻塞性肺疾病（COPD）和其他肺部疾病。然而，它不能用于评估区域功能和形态异常。目的定量评价COPD患者动态对比增强（DCE） CT肺灌注成像，并观察其与PFT、CT容积参数的相关性。材料与方法对63例COPD患者进行PFT和CT肺灌注检查。通过计算灌注缺损（HUdefect）与正常肺（HUnormal）的CT值比（RHU）来量化灌注缺损。利用容积CT数据计算肺气肿指数（EI）、肺总容积（TLV）和肺气肿总容积（TEV）。肺气肿实质定义为肺面积阈值低于-950 HU。采用Spearman相关分析评估RHU与TLV、TEV、EI和PFT的相关性。结果CT灌注图像上灌注缺损阳性率高于CT掩膜图像上肺气肿阳性率（χ2 = 17.027, P < 0.001）。Spearman相关检验显示，RHU与FEV1 （R = 0.59, P < 0.001）、FEV1%预测值（R = 0.61, P < 0.001）、FVC （R = 0.47, P = 0.002）、FEV1/FVC （R = 0.65, P < 0.001）呈正相关，与EI （R = -0.67, P < 0.001）呈负相关。结论CT灌注显像对CT表现不明显的肺气肿具有较高的检测灵敏度。RHU与PFT和CT容积参数相关，提示RHU在检测早期COPD变化方面更为敏感，可能是局灶性肺功能的潜在预测指标。
Background Pulmonary function test (PFT) is commonly used to help diagnose chronic obstructive pulmonary disease (COPD) and other lung diseases. However, it cannot be used to evaluate regional function and morphological abnormalities. Purpose To quantitatively evaluate pulmonary perfusion imaging using dynamic contrast-enhanced (DCE) computed tomography (CT) and observe its correlations with PFT and CT volumetric parameters in COPD patients. Material and Methods PFT and CT pulmonary perfusion examination were performed in 63 COPD patients. Perfusion defects were quantitated by calculating the CT value ratio (RHU) between perfusion defects (HUdefect) and normal lung (HUnormal). Volumetric CT data were used to calculate emphysema index (EI), total lung volume (TLV), and total emphysema volume (TEV). Emphysematous parenchyma was defined as the threshold of lung area lower than –950 HU. Correlations between RHU and TLV, TEV, EI, and PFT were assessed using Spearman correlation analysis. Results The positive rate of perfusion defects on CT perfusion images was higher than that of emphysema on CT mask images (χ2 = 17.027, P < 0.001). The Spearman correlation test showed that RHU was positively correlated with FEV1 (R = 0.59, P < 0.001), FEV1% Predicted (R = 0.61, P < 0.001), FVC (R = 0.47, P = 0.002), and FEV1/FVC (R = 0.65, P < 0.001), and negatively correlated with EI (R = –0.67, P < 0.001). Conclusion CT perfusion imaging is more sensitive in detecting emphysema that is inconspicuous on CT images. RHU is correlated with PFT and CT volumetric parameters, suggesting that it is more sensitive in detecting early COPD changes and may prove to be a potential predictor of focal lung function.
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影响因子：
4.8
作者：
Yamashiro, Tsuneo;Matsuoka, Shin;Bartholmai, Brian J.;Estepar, Raul San Jose;Ross, James C.;Diaz, Alejandro;Murayama, Sadayuki;Silverman, Edwin K.;Hatabu, Hiroto;Washko, George R.
通讯作者：
Washko, George R.
DOI：
--
发表时间：
2012
期刊：
--
影响因子：
--
作者：
Guangyuan Yu;Fan Li;Xia Yi;Li Xiaolin;Zhang Chenshi;L. Yuan;Yu Hong
通讯作者：
Guangyuan Yu;Fan Li;Xia Yi;Li Xiaolin;Zhang Chenshi;L. Yuan;Yu Hong
影响因子：
6.7
作者：
F. Molinari;C. Fink;F. Risse;S. Tuengerthal;L. Bonomo;H. Kauczor
通讯作者：
F. Molinari;C. Fink;F. Risse;S. Tuengerthal;L. Bonomo;H. Kauczor
影响因子：
5.9
作者：
Mets OM;Murphy K;Zanen P;Gietema HA;Lammers JW;van Ginneken B;Prokop M;de Jong PA
通讯作者：
de Jong PA
影响因子：
9.6
作者：
Zaporozhan, J;Ley, S;Kauczor, HU
通讯作者：
Kauczor, HU