The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease.
The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease.
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DOI：
10.1007/s00330-011-2237-9
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发表时间：
2012-01
影响因子：
5.9
通讯作者：
de Jong PA
中科院分区：
文献类型：
--
作者：
Mets OM;Murphy K;Zanen P;Gietema HA;Lammers JW;van Ginneken B;Prokop M;de Jong PA
在有和没有气流限制的当前和既往重度吸烟人群中，确定肺功能损害与定量计算机断层扫描（CT）测量的空气潴留和肺气肿之间的关系。在248例受试者中（50例正常吸烟者; 50例轻度梗阻; 50例中度梗阻; 50例重度梗阻; 48例极重度梗阻），使用几种可用的定量方法对成对的吸气和呼气末CT检查进行CT肺气肿和CT空气潴留定量。单因素和多因素线性回归分析显示，CT与肺功能指标（FEV 1、FEV 1/FVC、RV/TLC、Kco）相关。肺气肿和空气滞留的定量CT测量与气流限制密切相关（单变量r平方高达0.72，p < 0.001）。在多变量分析中，CT肺气肿和CT空气潴留的组合解释了受试者中68-83%的气流受限变异性，涵盖了气流受限的总范围（p < 0.001）。定量CT空气潴留和肺气肿测量的组合与当前和以前的重度吸烟者的肺功能损害密切相关，这些重度吸烟者具有广泛的气流限制。· CT有助于自动评估重度吸烟者的肺部疾病· CT定量测量重度吸烟者的肺气肿和小气道疾病· CT空气潴留和CT肺气肿与肺功能受损相关
To determine the relationship between lung function impairment and quantitative computed tomography (CT) measurements of air trapping and emphysema in a population of current and former heavy smokers with and without airflow limitation. In 248 subjects (50 normal smokers; 50 mild obstruction; 50 moderate obstruction; 50 severe obstruction; 48 very severe obstruction) CT emphysema and CT air trapping were quantified on paired inspiratory and end-expiratory CT examinations using several available quantification methods. CT measurements were related to lung function (FEV1, FEV1/FVC, RV/TLC, Kco) by univariate and multivariate linear regression analysis. Quantitative CT measurements of emphysema and air trapping were strongly correlated to airflow limitation (univariate r-squared up to 0.72, p < 0.001). In multivariate analysis, the combination of CT emphysema and CT air trapping explained 68-83% of the variability in airflow limitation in subjects covering the total range of airflow limitation (p < 0.001). The combination of quantitative CT air trapping and emphysema measurements is strongly associated with lung function impairment in current and former heavy smokers with a wide range of airflow limitation. • CT helps to automatically assess lung disease in heavy smokers • CT quantitatively measures emphysema and small airways disease in heavy smokers • CT air trapping and CT emphysema are associated with lung function impairment
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影响因子：
5.8
作者：
Agusti A;Calverley PM;Celli B;Coxson HO;Edwards LD;Lomas DA;MacNee W;Miller BE;Rennard S;Silverman EK;Tal-Singer R;Wouters E;Yates JC;Vestbo J;Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
通讯作者：
Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
影响因子：
5
作者：
Matsuoka, Shin;Kurihara, Yasuyuki;Nakajima, Yasuo
通讯作者：
Nakajima, Yasuo
影响因子：
19.7
作者：
Boedeker, KL;McNitt-Gray, MF;Goldin, JG
通讯作者：
Goldin, JG
影响因子：
9.6
作者：
Busacker A;Newell JD Jr;Keefe T;Hoffman EA;Granroth JC;Castro M;Fain S;Wenzel S
通讯作者：
Wenzel S
影响因子：
10
作者：
O'Donnell, RA;Peebles, C;Djukanovic, R
通讯作者：
Djukanovic, R