The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence.
The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence.
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DOI：
10.1007/s11136-011-0086-2
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发表时间：
2012-12
影响因子：
3.5
通讯作者：
Kuppermann, Miriam
中科院分区：
文献类型：
--
作者：
Pinto, Angela Marinilli;Subak, Leslee L.;Nakagawa, Sanae;Vittinghoff, Eric;Wing, Rena R.;Kusek, John W.;Herman, William H.;West, Delia Smith;Kuppermann, Miriam
To estimate the effect of change in weight and change in urinary incontinence (UI) frequency on changes in preference-based measures of health-related quality of life (HRQL) among overweight and obese women with UI participating in a weight loss trial. We conducted a longitudinal cohort analysis of 338 overweight and obese women with UI enrolled in a randomized clinical trial comparing a behavioral weight loss intervention to an educational control condition. At baseline, 6, and 18 months, health utilities were estimated using the Health Utilities Index Mark 3 (HUI3), a transformation of the SF-36 to the preference-based SF-6D, and the estimated Quality of Well-Being (eQWB) score (a summary calculated from the SF-36 physical functioning, mental health, bodily pain, general health perceptions, and role limitations-physical subscale scores). Potential predictors of changes in these outcomes were examined using generalized estimating equations. In adjusted multivariable models, weight loss was associated with improvement in HUI3, SF-6D, and eQWB at 6 and 18 months (p<.05). Increases in physical activity also were independently associated with improvement in HUI3 (p=.01) and SF-6D (p=.006) scores at 18 months. In contrast, reduction in UI frequency did not predict improvements in HRQL at 6 or 18 months. Weight loss and increased physical activity, but not reduction in UI frequency, were strongly associated with improvements in health utilities measured by the HUI3, SF-6D, and eQWB. These findings provide important information that can be used to inform cost-utility analyses of weight loss interventions.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
3.6
作者：
Horsman J;Furlong W;Feeny D;Torrance G
通讯作者：
Torrance G
影响因子：
3
作者：
Feeny, D;Furlong, W;Boyle, M
通讯作者：
Boyle, M
影响因子：
4.4
作者：
Drummond, M
通讯作者：
Drummond, M
影响因子：
3.5
作者：
Haywood, Kirstie L.;Garratt, Andrew M.;Lamb, Sarah E.
通讯作者：
Lamb, Sarah E.