QGRS-H Predictor: a web server for predicting homologous quadruplex forming G-rich sequence motifs in nucleotide sequences.
QGRS-H Predictor: a web server for predicting homologous quadruplex forming G-rich sequence motifs in nucleotide sequences.
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DOI：
10.1093/nar/gks422
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发表时间：
2012-07
影响因子：
14.9
通讯作者：
Bagga PS
中科院分区：
文献类型：
--
作者：
Menendez C;Frees S;Bagga PS
天然存在的G-四链体结构基序，由富含鸟嘌呤的核酸形成，已被报道存在于哺乳动物基因组的端粒、启动子和转录区。由于越来越多的证据表明它们在重要的生物过程、人类疾病和作为治疗靶点中的作用，G-四链体结构受到了极大的关注。最近，人们对RNA G-四链体作为转录后基因表达顺式调节元件的潜在作用产生了很大的兴趣。对G-四链体的大规模计算基因组学研究很难验证他们的预测，而不是在“湿”实验室中进行艰苦的测试。我们开发了一个生物信息学工具QGRS-H Predictor，它可以定位和分析mRNA、ncRNA和其他核苷酸序列中保守的推定四链体形成“G”富集序列（QGRS），例如启动子、端粒和基因侧翼区。识别保守的调控基序有助于验证计算并提高预测的准确性。QGRS-H Predictor特别适用于将同源G-四链体形成序列定位为5′和3′非翻译区的顺式调控元件，以及比对mRNA序列的CDS部分。QGRS-H Predictor具有高度交互式的数据图形表示。它是一个独特且用户友好的应用程序，为定义和研究G-四链体提供了许多选项。QGRS-H预测器可以在http://quadruplex.ramapo.edu/qgrs/app/start上免费访问。
Naturally occurring G-quadruplex structural motifs, formed by guanine-rich nucleic acids, have been reported in telomeric, promoter and transcribed regions of mammalian genomes. G-quadruplex structures have received significant attention because of growing evidence for their role in important biological processes, human disease and as therapeutic targets. Lately, there has been much interest in the potential roles of RNA G-quadruplexes as cis-regulatory elements of post-transcriptional gene expression. Large-scale computational genomics studies on G-quadruplexes have difficulty validating their predictions without laborious testing in ‘wet’ labs. We have developed a bioinformatics tool, QGRS-H Predictor that can map and analyze conserved putative Quadruplex forming 'G'-Rich Sequences (QGRS) in mRNAs, ncRNAs and other nucleotide sequences, e.g. promoter, telomeric and gene flanking regions. Identifying conserved regulatory motifs helps validate computations and enhances accuracy of predictions. The QGRS-H Predictor is particularly useful for mapping homologous G-quadruplex forming sequences as cis-regulatory elements in the context of 5′- and 3′-untranslated regions, and CDS sections of aligned mRNA sequences. QGRS-H Predictor features highly interactive graphic representation of the data. It is a unique and user-friendly application that provides many options for defining and studying G-quadruplexes. The QGRS-H Predictor can be freely accessed at: http://quadruplex.ramapo.edu/qgrs/app/start.
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影响因子：
4.1
作者：
Huijbregts, Lukas;Roze, Catherine;de Roux, Nicolas
通讯作者：
de Roux, Nicolas
影响因子：
14.9
作者：
Bugaut A;Balasubramanian S
通讯作者：
Balasubramanian S
DOI：
10.1083/jcb.136.4.761
发表时间：
1997-02-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bashkirov VI;Scherthan H;Solinger JA;Buerstedde JM;Heyer WD
通讯作者：
Heyer WD
影响因子：
5.8
作者：
Holland, R. C. G.;Down, T. A.;Pocock, M.;Prlic, A.;Huen, D.;James, K.;Foisy, S.;Draeger, A.;Yates, A.;Heuer, M.;Schreiber, M. J.
通讯作者：
Schreiber, M. J.
影响因子：
14.9
作者：
Halder K;Wieland M;Hartig JS
通讯作者：
Hartig JS