Episodic autobiographical memory is associated with variation in the size of hippocampal subregions
Episodic autobiographical memory is associated with variation in the size of hippocampal subregions
复制标题
情景自传体记忆与海马分区大小的变化有关
作者：
D. Palombo;Agnes Bacopulos;Robert S. C. Amaral;R. Olsen;R. Todd;A. Anderson;B. Levine
人类回忆过去事件的能力存在着显著的个体差异，然而，人们对这种个体差异的神经关联知之甚少。在实验室测量中，研究年轻人情景记忆的海马体积与个体差异的关系表明，整个海马体积与情景记忆无关（甚至负相关）。然而，海马体亚区的解剖和功能专门化表明，情景记忆的个体差异可能与特定的海马体亚区有关，而不是与整个海马体体积有关。考虑到DG/CA2/3回路被认为对支持人类情景记忆特别重要，我们预测该区域的体积将与情景记忆的个体差异有关。这一预测得到了海马体亚区高分辨率MRI和真实世界（自传式）情景记忆测量的支持。除了与DG/CA2/3相关外，我们还进一步观察到情景自传式记忆与耻骨下体积之间的关系，而与CA1或整个海马体积没有关联。这些发现提供了对现实世界中人类情景记忆个体差异的可能神经基质的深入了解。
Striking individual differences exist in the human capacity to recollect past events, yet, little is known about the neural correlates of such individual differences. Studies investigating hippocampal volume in relation to individual differences in laboratory measures of episodic memory in young adults suggest that whole hippocampal volume is unrelated (or even negatively associated) with episodic memory. However, anatomical and functional specialization across hippocampal subregions suggests that individual differences in episodic memory may be linked to particular hippocampal subregions, as opposed to whole hippocampal volume. Given that the DG/CA2/3 circuitry is thought to be especially critical for supporting episodic memory in humans, we predicted that the volume of this region would be associated with individual variability in episodic memory. This prediction was supported using high‐resolution MRI of the hippocampal subfields and measures of real‐world (autobiographical) episodic memory. In addition to the association with DG/CA2/3, we further observed a relationship between episodic autobiographical memory and subiculum volume, whereas no association was observed with CA1 or with whole hippocampal volume. These findings provide insight into the possible neural substrates that mediate individual differences in real‐world episodic remembering in humans.
影响因子：
3.5
作者：
Wisse, Laura E. M.;Daugherty, Ana M.;Olsen, Rosanna K.;Berron, David;Carr, Valerie A.;Stark, Craig E. L.;Amaral, Robert S. C.;Amunts, Katrin;Augustinack, Jean C.;Bender, Andrew R.;Bernstein, Jeffrey D.;Boccardi, Marina;Bocchetta, Martina;Burggren, Alison;Chakravarty, M. Mallar;Chupin, Marie;Ekstrom, Arne;de Flores, Robin;Insausti, Ricardo;Kanel, Prabesh;Kedo, Olga;Kennedy, Kristen M.;Kerchner, Geoffrey A.;LaRocque, Karen F.;Liu, Xiuwen;Maass, Anne;Malykhin, Nicolai;Mueller, Susanne G.;Ofen, Noa;Palombo, Daniela J.;Parekh, Mansi B.;Pluta, John B.;Pruessner, Jens C.;Raz, Naftali;Rodrigue, Karen M.;Schoemaker, Dorothee;Shafer, Andrea T.;Steve, Trevor A.;Suthana, Nanthia;Wang, Lei;Winterburn, Julie L.;Yassa, Michael A.;Yushkevich, Paul A.;la Joie, Renaud
通讯作者：
la Joie, Renaud