A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?
A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?
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DOI：
10.1002/hipo.22671
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发表时间：
2017-01
期刊：
影响因子：
3.5
通讯作者：
la Joie, Renaud
中科院分区：
文献类型：
--
作者：
Wisse, Laura E. M.;Daugherty, Ana M.;Olsen, Rosanna K.;Berron, David;Carr, Valerie A.;Stark, Craig E. L.;Amaral, Robert S. C.;Amunts, Katrin;Augustinack, Jean C.;Bender, Andrew R.;Bernstein, Jeffrey D.;Boccardi, Marina;Bocchetta, Martina;Burggren, Alison;Chakravarty, M. Mallar;Chupin, Marie;Ekstrom, Arne;de Flores, Robin;Insausti, Ricardo;Kanel, Prabesh;Kedo, Olga;Kennedy, Kristen M.;Kerchner, Geoffrey A.;LaRocque, Karen F.;Liu, Xiuwen;Maass, Anne;Malykhin, Nicolai;Mueller, Susanne G.;Ofen, Noa;Palombo, Daniela J.;Parekh, Mansi B.;Pluta, John B.;Pruessner, Jens C.;Raz, Naftali;Rodrigue, Karen M.;Schoemaker, Dorothee;Shafer, Andrea T.;Steve, Trevor A.;Suthana, Nanthia;Wang, Lei;Winterburn, Julie L.;Yassa, Michael A.;Yushkevich, Paul A.;la Joie, Renaud
高分辨率磁共振成像（MRI）的出现，使在体内研究在各种人群和疾病的结构和功能的海马子场和海马旁回的细分。由于许多现存的和高度不一致的分割协议，比较研究之间的结果是困难的。为了克服这一障碍，成立了海马子区域小组，作为一个国际合作组织，旨在制定一个协调一致的协议，用于在高分辨率MRI上手动分割海马和海马旁子区域。在这篇评论中，我们讨论了该协议的目标及其开发过程中涉及的相关关键挑战。这些包括现有解剖参考材料之间的差异，在测量的可靠性和解剖有效性之间取得适当的平衡，以及开发一种通用的协议，可用于研究年龄和健康状况不同的人群。评注概述了这些关键挑战以及每一项挑战的拟议解决办法，并列举了我们工作计划中的具体例子。最后，通过两个例子，我们说明了如何协调协议，一旦完成，预计将影响该领域产生的测量是定量可比的实验室，并通过促进不同的研究结果的合成。
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Due to the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include differences among existing anatomical reference materials, striking the right balance between reliability of measurements and anatomical validity, and the development of a versatile protocol that can be adopted for the study of populations varying in age and health. The commentary outlines these key challenges, as well as the proposed solution of each, with concrete examples from our working plan. Finally, with two examples, we illustrate how the harmonized protocol, once completed, is expected to impact the field by producing measurements that are quantitatively comparable across labs and by facilitating the synthesis of findings across different studies.
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影响因子：
3.5
作者：
Daugherty AM;Bender AR;Raz N;Ofen N
通讯作者：
Ofen N
影响因子：
5.7
作者：
La Joie, Renaud;Fouquet, Marine;Chetelat, Gael
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Chetelat, Gael
使用高分辨率功能磁共振成像对人类内侧颞叶进行成像。
影响因子：
16.2
作者：
Carr, Valerie A.;Rissman, Jesse;Wagner, Anthony D.
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Wagner, Anthony D.
人类海马子场中的多素模式分析。
影响因子：
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作者：
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通讯作者：
Maguire EA
影响因子：
5.7
作者：
Feinberg, David A.;Yacoub, Essa
通讯作者：
Yacoub, Essa