Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars.
Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars.
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DOI：
10.2337/dc18-0071
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发表时间：
2018-08
期刊：
影响因子：
16.2
通讯作者：
Yki-Järvinen H
中科院分区：
文献类型：
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作者：
Luukkonen PK;Sädevirta S;Zhou Y;Kayser B;Ali A;Ahonen L;Lallukka S;Pelloux V;Gaggini M;Jian C;Hakkarainen A;Lundbom N;Gylling H;Salonen A;Orešič M;Hyötyläinen T;Orho-Melander M;Rissanen A;Gastaldelli A;Clément K;Hodson L;Yki-Järvinen H
非酒精性脂肪性肝病(即肝脏内甘油三酯[IHTG]含量增加)，易患2型糖尿病和心血管疾病。脂肪组织脂解和肝脏新生脂肪生成(DNL)是导致IHTG的主要途径。我们假设膳食中的常量营养素成分会影响体重增加引起的IHTG变化的途径、媒介和幅度。38名超重受试者(年龄48±2岁，体重指数31±1 kg/m2，肝脂4.7±0.9%)每天额外摄入1000大卡饱和(SAT)或不饱和(UNSAT)脂肪或单糖(CARB)，持续3周。我们在0周和3周检测了IHTG(1H-MRS)、基础状态下和正常血糖高胰岛素血症期间的IHTG途径(脂解([2H5]甘油)和DNL(2H2O))、胰岛素抵抗、内毒素血症、血浆神经酰胺和脂肪组织基因表达。过量喂养SAT使IHTG增加(+55%)，高于UNSAT(+15%，P<；0.05)。CARB通过刺激DNL增加IHTG(+33%)(+98%)。Sat显著升高，而USAT则降低脂解作用。Sat可引起胰岛素抵抗和内毒素血症，并使多种血浆神经酰胺显著升高。日粮对脂肪组织基因表达有明显影响。过量能量的常量营养素组成影响IHTG的途径：Carb增加DNL，SAT增加，UNSAT减少脂解。Sat诱导的IHTG、胰岛素抵抗和有害神经酰胺的增加最大。减少SAT的摄入可能有益于降低IHTG和相关的糖尿病风险。
Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG. We overfed 38 overweight subjects (age 48 ± 2 years, BMI 31 ± 1 kg/m2, liver fat 4.7 ± 0.9%) 1,000 extra kcal/day of saturated (SAT) or unsaturated (UNSAT) fat or simple sugars (CARB) for 3 weeks. We measured IHTG (1H-MRS), pathways contributing to IHTG (lipolysis ([2H5]glycerol) and DNL (2H2O) basally and during euglycemic hyperinsulinemia), insulin resistance, endotoxemia, plasma ceramides, and adipose tissue gene expression at 0 and 3 weeks. Overfeeding SAT increased IHTG more (+55%) than UNSAT (+15%, P < 0.05). CARB increased IHTG (+33%) by stimulating DNL (+98%). SAT significantly increased while UNSAT decreased lipolysis. SAT induced insulin resistance and endotoxemia and significantly increased multiple plasma ceramides. The diets had distinct effects on adipose tissue gene expression. Macronutrient composition of excess energy influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT decreases lipolysis. SAT induced the greatest increase in IHTG, insulin resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial in reducing IHTG and the associated risk of diabetes.
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影响因子：
7.1
作者：
Bjermo, Helena;Iggman, David;Riserus, Ulf
通讯作者：
Riserus, Ulf
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
8.2
作者：
Summers, LKM;Fielding, BA;Frayn, KN
通讯作者：
Frayn, KN
影响因子：
7.1
作者：
Sevastianova, Ksenia;Santos, Alexandre;Yki-Jarvinen, Hannele
通讯作者：
Yki-Jarvinen, Hannele
影响因子：
16.2
作者：
通讯作者：
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