Particulate matter exposure is highly correlated to pediatric asthma exacerbation.
Particulate matter exposure is highly correlated to pediatric asthma exacerbation.
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DOI：
10.18632/aging.203281
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发表时间：
2021-07-13
期刊：
影响因子：
--
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Yang X;Zhang Y;Zhan X;Xu X;Li S;Xu X;Ying S;Chen Z
哮喘是一种异质性疾病，环境因素在其中起着重要作用，颗粒物（PM）对哮喘发生和严重程度的影响正受到越来越多的关注。本研究旨在探讨PM与儿童哮喘急性发作的相关性及其可能机制。收集某大学三级儿童医院2013年1月至2017年12月哮喘就诊数据（N = 16，779，739），分析哮喘就诊与当地PM浓度的关系。为进一步研究，我们建立了屋尘螨（HDM）诱导的过敏性气道炎症模型与PM干预。我们检测到PM浓度和儿童哮喘就诊之间的相关性，特别是在6岁以下的儿童中。体内实验结果表明PM加重了HDM诱导的气道炎症，IL-33中和抗体对气道炎症有保护作用。我们的研究表明PM是促进儿童哮喘急性发作的危险因素，IL-33可能是一个有希望的靶点。
Asthma is a heterogeneous disease in which environmental factors play an important role, and the effect of particulate matter (PM) on the occurrence and severity of asthma is drawing more attention. This study aims to identify the correlation between PM and pediatric asthma exacerbation and explore the potential mechanisms. The asthma visits data (N = 16,779,739) in a university-based tertiary children’s hospital from January 2013 to December 2017 were collected, and the relationship between asthma visits and local PM concentration was analyzed. For further study, we established a house dust mite (HDM)-induced allergic airway inflammation model with PM intervention. We detected a correlation between PM concentration and pediatric asthma visits, especially in children under 6 years old. The in vivo data showed that PM aggravated HDM-induced airway inflammation, and IL-33 neutralizing antibody exerted a protective role. Our study suggests that PM is a risk factor in promoting pediatric asthma exacerbation, in which IL-33 might be a promising target.
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