Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy?
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy?
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DOI：
10.1038/s41577-021-00656-2
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Perlman S
中科院分区：
文献类型：
--
作者：
Wong LR;Perlman S
人类冠状病毒导致一系列疾病，从轻微的普通感冒到急性呼吸窘迫综合征和死亡。严重急性呼吸综合征冠状病毒(SARS-CoV)、中东呼吸综合征冠状病毒和SARS-CoV-2这三种高致病性人类冠状病毒已经说明了人类冠状病毒的流行和大流行潜力，迫切需要更好地了解它们的致病机制，以便合理设计治疗方案。对患者的分析显示，在严重的人类冠状病毒感染病例中，免疫系统明显失调，有充分的证据表明，对人类冠状病毒的异常免疫反应以干扰素诱导受损、旺盛的炎症反应和延迟的适应性免疫反应为典型。此外，各种病毒蛋白已被证明削弱干扰素的诱导和信号传递，并诱导炎性小体激活。这表明与人类冠状病毒相关的严重疾病是由失调的宿主免疫反应和主动的病毒干扰所介导的。在这里，我们讨论我们目前对这些情景中涉及的机制的理解。从这个角度出发，王乐贤和史丹利·珀尔曼研究了严重急性呼吸综合征冠状病毒2(SARS-CoV-2)和相关冠状病毒是如何导致免疫失调和免疫病理的。它们概述了冠状病毒衍生的分子干扰关键的先天性免疫反应，包括干扰素途径和补体，核因子-κB信号和炎症体激活，以及与宿主适应性免疫的激活。
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds to acute respiratory distress syndrome and death. Three highly pathogenic human coronaviruses — severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus and SARS-CoV-2 — have illustrated the epidemic and pandemic potential of human coronaviruses, and a better understanding of their disease-causing mechanisms is urgently needed for the rational design of therapeutics. Analyses of patients have revealed marked dysregulation of the immune system in severe cases of human coronavirus infection, and there is ample evidence that aberrant immune responses to human coronaviruses are typified by impaired induction of interferons, exuberant inflammatory responses and delayed adaptive immune responses. In addition, various viral proteins have been shown to impair interferon induction and signalling and to induce inflammasome activation. This suggests that severe disease associated with human coronaviruses is mediated by both dysregulated host immune responses and active viral interference. Here we discuss our current understanding of the mechanisms involved in each of these scenarios. In this Perspective, Lok-Yin Roy Wong and Stanley Perlman consider how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses are able to drive immune dysregulation and immunopathology. They provide an overview of the coronavirus-derived molecules that interfere with key innate immune responses, including interferon pathways and complement, NF-κB signalling and inflammasome activation, as well as with the activation of host adaptive immunity.
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影响因子：
12.8
作者：
Cugno M;Meroni PL;Gualtierotti R;Griffini S;Grovetti E;Torri A;Lonati P;Grossi C;Borghi MO;Novembrino C;Boscolo M;Uceda Renteria SC;Valenti L;Lamorte G;Manunta M;Prati D;Pesenti A;Blasi F;Costantino G;Gori A;Bandera A;Tedesco F;Peyvandi F
通讯作者：
Peyvandi F
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影响因子：
17.1
作者：
Bilich T;Nelde A;Heitmann JS;Maringer Y;Roerden M;Bauer J;Rieth J;Wacker M;Peter A;Hörber S;Rachfalski D;Märklin M;Stevanović S;Rammensee HG;Salih HR;Walz JS
通讯作者：
Walz JS
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
56.9
作者：
Broggi, Achille;Ghosh, Sreya;Zanoni, Ivan
通讯作者：
Zanoni, Ivan
影响因子：
24.8
作者：
Goel RR;Apostolidis SA;Painter MM;Mathew D;Pattekar A;Kuthuru O;Gouma S;Hicks P;Meng W;Rosenfeld AM;Dysinger S;Lundgreen KA;Kuri-Cervantes L;Adamski S;Hicks A;Korte S;Oldridge DA;Baxter AE;Giles JR;Weirick ME;McAllister CM;Dougherty J;Long S;D'Andrea K;Hamilton JT;Betts MR;Luning Prak ET;Bates P;Hensley SE;Greenplate AR;Wherry EJ
通讯作者：
Wherry EJ