T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals.
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals.
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T细胞和抗体动力学描述了介导共证疗法个体中介导长期免疫反应的SARS-COV-2肽。
DOI：
10.1126/scitranslmed.abf7517
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发表时间：
2021-04-21
影响因子：
17.1
通讯作者：
Walz JS
中科院分区：
文献类型：
--
作者：
Bilich T;Nelde A;Heitmann JS;Maringer Y;Roerden M;Bauer J;Rieth J;Wacker M;Peter A;Hörber S;Rachfalski D;Märklin M;Stevanović S;Rammensee HG;Salih HR;Walz JS
对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的长期免疫记忆对于群体水平免疫的发展至关重要，这是疫苗接种方法的目的。关于抗体滴度迅速下降的报告导致了关于单独体液免疫的功效的问题。2019年冠状病毒病（COVID-19）后T细胞记忆的相关性仍不清楚。在这里，我们研究了SARS-CoV-2抗体和T细胞反应在COVID-19恢复期个体感染后长达6个月的匹配样本中。纵向分析显示，减少和稳定的穗和核蛋白特异性抗体反应，分别。相比之下，功能性T细胞应答在频率和强度上保持稳健，甚至增加。T细胞多样性随时间的单肽图谱鉴定了介导长期SARS-CoV-2 T细胞应答的开放阅读框架独立的显性T细胞表位。这些表位的鉴定可能是COVID-19疫苗设计的基础。纵向分析确定了COVID-19恢复期个体持久记忆T细胞应答的SARS-CoV-2肽靶点。
Long-term immunological memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for the development of population-level immunity, which is the aim of vaccination approaches. Reports on rapidly decreasing antibody titers have led to questions regarding the efficacy of humoral immunity alone. The relevance of T cell memory after coronavirus disease 2019 (COVID-19) remains unclear. Here, we investigated SARS-CoV-2 antibody and T cell responses in matched samples of COVID-19 convalescent individuals up to six months post-infection. Longitudinal analysis revealed decreasing and stable spike- and nucleocapsid-specific antibody responses, respectively. In contrast, functional T cell responses remained robust, and even increased, in both frequency and intensity. Single peptide mapping of T cell diversity over time identified open reading frame-independent, dominant T cell epitopes mediating long-term SARS-CoV-2 T cell responses. Identification of these epitopes may be fundamental for COVID-19 vaccine design. Longitudinal analysis identifies SARS-CoV-2 peptide targets of durable memory T cell responses in COVID-19 convalescent individuals.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
5.4
作者：
Arlehamn, Cecilia S. Lindestam;Lewinsohn, David;Lewinsohn, Deborah
通讯作者：
Lewinsohn, Deborah
影响因子：
6.4
作者：
Boyle, LH;Goodall, JC;Gaston, JSH
通讯作者：
Gaston, JSH
影响因子：
158.5
作者：
Keech, Cheryl;Albert, Gary;Glenn, Gregory M.
通讯作者：
Glenn, Gregory M.
影响因子：
100.3
作者：
Chen, Zeyu;John Wherry, E.
通讯作者：
John Wherry, E.