Cuffless blood pressure monitoring from a wristband with calibration-free algorithms for sensing location based on bio-impedance sensor array and autoencoder.

Cuffless blood pressure monitoring from a wristband with calibration-free algorithms for sensing location based on bio-impedance sensor array and autoencoder.
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DOI:
10.1038/s41598-021-03612-1
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发表时间:
2022-01-10
期刊:
影响因子:
4.6
通讯作者:
Jafari R
Jafari R
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Ibrahim B;Jafari R

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连续监测血压对于预测和预防心血管疾病是必不可少的。基于集成到可穿戴设备中的非侵入性传感器的无袖珍BP方法可以将血液搏动活动转换为连续的BP数据。然而,可穿戴设备的局部血液脉动传感器存在基于浅表毛细血管的脉动活动测量不准确、设备外形因数较大以及血压随传感器位置变化等问题,从而降低了血压估计的准确性和设备的耐磨性。本研究提出了一种基于新型生物阻抗(Bio-Z)传感器阵列的无袖带血压监测方法,该传感器阵列构建在具有小尺寸因数的柔性腕带中,可以提供稳健的血液脉搏传感和血压估计,而不需要对传感位置进行校准。我们使用卷积神经网络(CNN)自动编码器,从传感器阵列中的一组六个Bio-Z传感器重建与传感位置无关的动脉脉搏信号的准确估计。我们依赖于自适应增强回归模型,该模型将估计的动脉脉搏信号的特征映射到收缩压和舒张压读数。平均误差和相关系数分别为:舒张压0.5 ± 5.0 mm Hg和0.80;收缩压0.2 ± 6.5 mm Hg和0.79。
Continuous monitoring of blood pressure (BP) is essential for the prediction and the prevention of cardiovascular diseases. Cuffless BP methods based on non-invasive sensors integrated into wearable devices can translate blood pulsatile activity into continuous BP data. However, local blood pulsatile sensors from wearable devices suffer from inaccurate pulsatile activity measurement based on superficial capillaries, large form-factor devices and BP variation with sensor location which degrade the accuracy of BP estimation and the device wearability. This study presents a cuffless BP monitoring method based on a novel bio-impedance (Bio-Z) sensor array built in a flexible wristband with small-form factor that provides a robust blood pulsatile sensing and BP estimation without calibration methods for the sensing location. We use a convolutional neural network (CNN) autoencoder that reconstructs an accurate estimate of the arterial pulse signal independent of sensing location from a group of six Bio-Z sensors within the sensor array. We rely on an Adaptive Boosting regression model which maps the features of the estimated arterial pulse signal to systolic and diastolic BP readings. BP was accurately estimated with average error and correlation coefficient of 0.5 ± 5.0 mmHg and 0.80 for diastolic BP, and 0.2 ± 6.5 mmHg and 0.79 for systolic BP, respectively.
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