Sonic hedgehog is required for the assembly and remodeling of branchial arch blood vessels.
Sonic hedgehog is required for the assembly and remodeling of branchial arch blood vessels.
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DOI：
10.1002/dvdy.21608
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发表时间：
2008-07
影响因子：
2.5
通讯作者：
Grim, Milos
中科院分区：
文献类型：
--
作者：
Kolesova, Hana;Roelink, Henk;Grim, Milos
Sonic hedgehog（Shh）是一种参与许多发育过程的形态发生素。注射产生Shh阻断抗体的细胞（5E1）导致Shh反应的减弱，并且这导致血管畸形和受损的重塑，其特征在于前主静脉和流出道的扩张和突出、背侧动脉的延迟融合、颈内动脉的受损分支和主动脉弓的延迟重塑。血管壁中平滑肌细胞的分布不变。在5E1注射的胚胎中，我们还观察到内皮细胞组装成血管管受损，特别是在第六鳃弓、前主静脉周围和背主动脉周围。在5E1处理的胚胎中，在头部间充质中观察到巨噬细胞样细胞数量增加，凋亡细胞和增殖水平降低。总之，这些观察结果表明，Shh信号传导在多个阶段是正确的血管形成和重塑所必需的。
Sonic hedgehog (Shh) is a morphogen involved in many developmental processes. Injection of cells (5E1) that produce a Shh blocking antibody, causes an attenuation of the Shh response, and this causes vascular malformations and impaired remodeling characterized by hemorrhages and protrusions of the anterior cardinal vein and outflow tract, delayed fusion of the dorsal aortae, impaired branching of the internal carotid artery and delayed remodeling of the aortic arches. Distribution of smooth muscle cells in the vessel wall is unchanged. In 5E1 injected embryos we also observed impaired assembly of endothelial cells into vascular tubes, particularly in the sixth branchial arch, around the anterior cardinal vein and around dorsal aorta. In 5E1 treated embryos, increased numbers of macrophage-like cells, apoptotic cells and a decreased level of proliferation were observed in head mesenchyme. Together these observations show that Shh signaling is required at multiple stages for proper vessel formation and remodeling.
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DOI：
10.1073/pnas.93.18.9346
发表时间：
1996-09-03
影响因子：
11.1
作者：
Marigo, V;Tabin, CJ
通讯作者：
Tabin, CJ
DOI：
10.1007/s00429-004-0396-z
发表时间：
2004-06-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
Nimmagadda, S;Loganathan, PG;Huang, R
通讯作者：
Huang, R
影响因子：
2.7
作者：
van Tuyl, Minke;Groenman, Freek;Post, Martin
通讯作者：
Post, Martin
影响因子：
0.9
作者：
Nagase, Takashi;Nagase, Miki;Yamagishi, Masaaki
通讯作者：
Yamagishi, Masaaki
影响因子：
4.6
作者：
Astorga, Jeanette;Carlsson, Peter
通讯作者：
Carlsson, Peter