Tumor angiogenesis is associated with MUC1 overexpression and loss of prostate-specific antigen expression in prostate cancer.
Tumor angiogenesis is associated with MUC1 overexpression and loss of prostate-specific antigen expression in prostate cancer.
复制标题
肿瘤血管生成与前列腺癌中 MUC1 过度表达和前列腺特异性抗原表达丧失相关。
DOI：
--
复制
发表时间：
2001
影响因子：
11.5
通讯作者：
M. Koukourakis
中科院分区：
文献类型：
--
作者：
Ilias Papadopoulos;E. Sivridis;A. Giatromanolaki;M. Koukourakis
前列腺癌的生物学潜能是高度可变的，并且不能仅通过组织病理学标准令人满意地预测。因此，需要更多和更精确的信息。虽然血管生成已被认为在许多人类癌症中具有预后重要性，并且MUC 1（也称为episialin）被认为是转移发展的原因，但这些参数在前列腺癌中的作用仍不清楚。本研究的目的是调查是否血管生成，评估微血管密度（MVD），与前列腺肿瘤MUC 1和前列腺特异性抗原（PSA）的表达或诊断时的组织病理学分级，并确定是否这些因素可能提供额外的信息，关于前列腺肿瘤生物学。采用免疫组化方法检测60例前列腺癌石蜡包埋标本中的MVD，用单克隆抗体CD 31检测MVD，用单克隆抗体CCE 831和ER-PR 8检测MUC 1和PSA的表达。根据Gleason分级系统对肿瘤进行分类。MUC 1过表达与肿瘤内高血管生成显著相关（P = 0.02）。相反，前列腺癌细胞PSA高表达与MVD低相关（P = 0.03）。MUC 1与PSA表达无相关性。通常，高级别肿瘤不表达PSA，并倾向于显示血管生成增加。然而，这些差异不具有统计学意义。同样，组织学分级与MUC 1表达或血管生成之间也没有统计学显著相关性。这表明PSA可能对前列腺癌中新血管形成具有直接抑制作用，而MUC 1在该肿瘤中的表达可能与血管生成表型有关。显然需要进一步的研究来阐明这些蛋白质在前列腺癌中的确切作用。
The biological potential of prostate cancer is highly variable and cannot be satisfactorily predicted by histopathological criteria alone. Therefore, additional and more precise information is desirable. Although angiogenesis has been suggested as being of prognostic importance in many human cancers, and MUC1, also known as episialin, was thought to be responsible for the development of metastasis, the role of these parameters in prostate cancer remains unclear. The aim of this study was to investigate whether angiogenesis, assessed as microvessel density (MVD), was correlated with the expression of prostate tumor MUC1 and prostate-specific antigen (PSA) or with histopathological grade at diagnosis, and to determine whether any of these factors might provide additional information with regard to prostate tumor biology. Paraffin-embedded material from 60 patients with prostate carcinoma was examined immunohistochemically, using the monoclonal antibody CD31 to determine MVD, and the monoclonal antibodies CCE831 and ER-PR8 to assess MUC1 and PSA expression, respectively. The tumors were categorized according to the Gleason grading system. MUC1 overexpression was significantly related to a high intratumoral angiogenesis (P = 0.02). By contrast, a high PSA expression by prostate cancer cells was associated with low MVD (P = 0.03). No correlation was found between MUC1 and PSA expression. Usually, high-grade tumors were not PSA-expressive and tended to display increased angiogenesis. These differences, however, were not of statistical significance. Similarly, there was no statistically significant association between histological grade and MUC1 expression or angiogenesis. It is suggested that PSA may have a direct suppressive effect on new blood vessel formation in prostate cancer, whereas the expression of MUC1 in this tumor may be connected with an angiogenic phenotype. Additional studies are obviously needed to clarify the precise role of these proteins in prostate cancer.
影响因子：
2.1
作者：
Duque, JLF;Loughlin, KR;Freeman, MR
通讯作者：
Freeman, MR