The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers.
The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers.
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DOI：
10.1038/s41598-018-34378-8
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发表时间：
2018-10-31
影响因子：
4.6
通讯作者：
Chang TC
中科院分区：
文献类型：
--
作者：
Tseng TY;Chen WW;Chu IT;Wang CL;Chang CC;Lin MC;Lou PJ;Chang TC
使用时间门控荧光寿命成像显微镜，显着更多的信号从3，6-双（1-甲基-2-乙烯基-吡啶）咔唑二碘（o-BMVC）焦点，其特征在于更长的荧光衰减时间o-BMVC，检测到6种类型的癌细胞比在3种类型的正常细胞。越来越多的证据表明o-BMVC灶主要是G-四链体灶。o-BMVC病灶数量的大对比度可以被认为是区分癌细胞与正常细胞的常见特征。组织活检的进一步研究表明，o-BMVC测试为头颈癌的临床检测提供了高准确性。
Using time-gated fluorescence lifetime imaging microscopy, significantly more signals from 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide (o-BMVC) foci, characterized by the longer fluorescent decay time of o-BMVC, were detected in six types of cancer cells than in three types of normal cells. Accumulating evidence suggested that the o-BMVC foci are mainly the G-quadruplex foci. The large contrast in the number of o-BMVC foci can be considered as a common signature to distinguish cancer cells from normal cells. Further study of tissue biopsy showed that the o-BMVC test provides a high accuracy for clinical detection of head and neck cancers.
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影响因子：
46.9
作者：
Chambers, Vicki S.;Marsico, Giovanni;Balasubramanian, Shankar
通讯作者：
Balasubramanian, Shankar
DOI：
10.1038/nrg3296
发表时间：
2012-11
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
62.1
作者：
Kobayashi, Hisataka;Ogawa, Mikako;Alford, Raphael;Choyke, Peter L.;Urano, Yasuteru
通讯作者：
Urano, Yasuteru
影响因子：
15
作者：
Laguerre, Aurelien;Hukezalie, Kyle;Monchaud, David
通讯作者：
Monchaud, David
影响因子：
16.6
作者：
Limongelli, Vittorio;De Tito, Stefano;Parrinello, Michele
通讯作者：
Parrinello, Michele