Construction Noise Induces Hypercoagulability and Elevated Plasma Corticosteroids in Rats
Construction Noise Induces Hypercoagulability and Elevated Plasma Corticosteroids in Rats
复制标题
建筑噪音引起大鼠高凝状态和血浆皮质类固醇升高
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
M. Othman
中科院分区：
文献类型：
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作者：
M. Toukh;S. P. Gordon;M. Othman
尽管为研究目的而饲养的动物受到严格的光照、温度和湿度监测，但声学环境受到的关注较少。在一项回顾性研究中，我们使用血栓弹性成像技术研究了建筑噪声对健康对照大鼠凝血的影响。由于饲养这些老鼠的动物护理设施附近的施工，动物无意中暴露在噪音中。我们将结果与年龄、性别匹配的未暴露大鼠进行了比较。反应(R)时间明显缩短（P = 0.009），凝血指数有升高趋势（CI; P = 0.09），提示高凝性。R时间短和CI增加与血浆皮质醇和皮质酮升高相关，表明这些大鼠的高凝性是应激引起的。噪声是动物需要监测的应激因素，特别是如果这些动物被选为止血研究的对照。
Although animals housed for research purposes are strictly monitored for lighting, temperature, and humidity, the acoustic environment receives less attention. In a retrospective study, we investigated the effect of construction-induced noise on coagulation using thromboelastography in a group of healthy control rats. Animals were unintentionally exposed to noise due to construction in the vicinity of the animal care facility where these rats were housed. We compared the results to those of age-, gender-matched nonexposed rats. There was a significant shortening of the reaction (R) time (P = .009) and a trend toward an increase in coagulation index (CI; P = .09), indicating hypercoagulability. The short R time and increase in CI were correlated with an elevated plasma cortisol and corticosterone, indicating that the hypercoagulability seen in these rats is stress induced. Noise is a stress factor for which animals need to be monitored, particularly if those animals are selected as controls for hemostasis studies.
影响因子：
0.8
作者：
J. Turner;Jennifer L. Parrish;L. Hughes;L. Toth;D. Caspary
通讯作者：
J. Turner;Jennifer L. Parrish;L. Hughes;L. Toth;D. Caspary