Space-Time Trends in Lassa Fever in Sierra Leone by ELISA Serostatus, 2012-2019.
Space-Time Trends in Lassa Fever in Sierra Leone by ELISA Serostatus, 2012-2019.
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DOI：
10.3390/microorganisms9030586
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发表时间：
2021-03-12
期刊：
影响因子：
4.5
通讯作者：
The Viral Hemorrhagic Fever Consortium
中科院分区：
文献类型：
--
作者：
Shaffer JG;Schieffelin JS;Momoh M;Goba A;Kanneh L;Alhasan F;Gbakie M;Engel EJ;Bond NG;Hartnett JN;Nelson DKS;Bush DJ;Boisen ML;Heinrich ML;Rowland MM;Branco LM;Samuels RJ;Garry RF;Grant DS;The Viral Hemorrhagic Fever Consortium
拉沙热（LF）是一种在撒哈拉以南非洲发现的病毒性出血性疾病，每年造成多达30万例病例和5000例死亡。LF在塞拉利昂，特别是在其东部省是高度流行的。凯内马政府医院（KGH）是世界上仅有的几个全年进行诊断检测的LF隔离设施之一。在这里，我们重点关注2012年至2019年期间在塞拉利昂发生的LF的时空趋势，以提供2014-2016年埃博拉疫情后LF的经常账户。数据进行了分析，3277例疑似LF病例，并分类为急性，近期，非LF或使用酶联免疫吸附试验（ELISA）的LF暴露前。急性、近期和非LF或既往LF暴露的出现率分别为6.0%（195/3277）、25.6%（838/3277）和68.4%（2244/3277）。在2051例非LF或既往LF暴露者中，33.2%（682/2051）的患者在恢复期LF暴露中检测为阳性。LF病死率为78.5%（106/135）。埃博拉疫情后，临床表现和确诊LF病例均有所下降。这些下降与疾病发作和临床表现之间的持续时间增加相吻合，这可能表明疾病更严重或在疾病后期出现。急性LF病例及其相应的CFR在旱季（11月至4月）达到高峰。近期（但不是急性）接触LF的受试者更可能出现在雨季（5月至10月）而不是旱季（p < 0.001）。这里的调查结果表明，LF仍然在塞拉利昂流行，案件量可能会恢复到埃博拉疫情之前的水平。这些结果提供了对塞拉利昂LF目前流行病学概况的了解，以促进LF疫苗研究，并强调LF队列研究和LF诊断持续进步的必要性。
Lassa fever (LF) is a viral hemorrhagic disease found in Sub-Saharan Africa and is responsible for up to 300,000 cases and 5000 deaths annually. LF is highly endemic in Sierra Leone, particularly in its Eastern Province. Kenema Government Hospital (KGH) maintains one of only a few LF isolation facilities in the world with year-round diagnostic testing. Here we focus on space-time trends for LF occurring in Sierra Leone between 2012 and 2019 to provide a current account of LF in the wake of the 2014–2016 Ebola epidemic. Data were analyzed for 3277 suspected LF cases and classified as acute, recent, and non-LF or prior LF exposure using enzyme-linked immunosorbent assays (ELISAs). Presentation rates for acute, recent, and non-LF or prior LF exposure were 6.0% (195/3277), 25.6% (838/3277), and 68.4% (2244/3277), respectively. Among 2051 non-LF or prior LF exposures, 33.2% (682/2051) tested positive for convalescent LF exposure. The overall LF case-fatality rate (CFR) was 78.5% (106/135). Both clinical presentations and confirmed LF cases declined following the Ebola epidemic. These declines coincided with an increased duration between illness onset and clinical presentation, perhaps suggesting more severe disease or presentation at later stages of illness. Acute LF cases and their corresponding CFRs peaked during the dry season (November to April). Subjects with recent (but not acute) LF exposure were more likely to present during the rainy season (May to October) than the dry season (p < 0.001). The findings here suggest that LF remains endemic in Sierra Leone and that caseloads are likely to resume at levels observed prior to the Ebola epidemic. The results provide insight on the current epidemiological profile of LF in Sierra Leone to facilitate LF vaccine studies and accentuate the need for LF cohort studies and continued advancements in LF diagnostics.
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影响因子：
158.5
作者：
MCCORMICK, JB;KING, IJ;BELMONTWILLIAMS, R
通讯作者：
BELMONTWILLIAMS, R
影响因子：
2.8
作者：
Bolkan, Hakon A.;van Duinen, Alex;von Schreeb, Johan
通讯作者：
von Schreeb, Johan
影响因子：
8.1
作者：
Jones, Susan A.;Gopalakrishnan, Somasundari;van den Broek, Nynke R.
通讯作者：
van den Broek, Nynke R.
影响因子：
3.8
作者：
Fichet-Calvet, Elisabeth;Rogers, David John
通讯作者：
Rogers, David John
DOI：
10.1093/trstmh/trx009
发表时间：
2017-01-01
影响因子：
2.2
作者：
Camara BS;Delamou A;Diro E;Béavogui AH;El Ayadi AM;Sidibé S;Grovogui FM;Takarinda KC;Bouedouno P;Sandouno SD;Okumura J;Baldé MD;Van Griensven J;Zachariah R
通讯作者：
Zachariah R