Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids.
Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids.
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DOI：
10.1021/jf104742n
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发表时间：
2011-03-09
影响因子：
6.1
通讯作者：
Gloer JB
中科院分区：
文献类型：
--
作者：
Sobolev VS;Khan SI;Tabanca N;Wedge DE;Manly SP;Cutler SJ;Coy MR;Becnel JJ;Neff SA;Gloer JB
The peanut plant (Arachis hypogaea L.), when infected by a microbial pathogen, is capable of producing stilbene-derived compounds that are considered antifungal phytoalexins. In addition, the potential health benefits of other stilbenoids from peanuts, including resveratrol and pterostilbene, have been acknowledged by several investigators. Despite considerable progress in peanut research, relatively little is known about the biological activity of the stilbenoid phytoalexins. This study investigated the activities of some of these compounds in a broad spectrum of biological assays. Since peanut stilbenoids appear to play roles in plant defense mechanisms, they were evaluated for their effects on economically important plant pathogenic fungi of the genera Colletotrichum, Botrytis, Fusarium, and Phomopsis. We further investigated these peanut phytoalexins, together with some related natural and synthetic stilbenoids (a total of 24 compounds) in a panel of bioassays to determine their anti-inflammatory, cytotoxic, and antioxidant activities in mammalian cells. Several of these compounds were also evaluated as mammalian opioid receptor competitive antagonists. Assays for adult mosquito and larvae toxicity were also performed. The results of these studies reveal that peanut stilbenoids, as well as related natural and synthetic stilbene derivatives, display a diverse range of biological activities.
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影响因子：
2.1
作者：
Pridgeon, Julia W.;Becnel, James J.;Linthicum, Kenneth J.
通讯作者：
Linthicum, Kenneth J.
影响因子：
1.9
作者：
Mustafa, J;Khan, SI;Khan, IA
通讯作者：
Khan, IA
影响因子：
2.7
作者：
Reddy, Muntha K.;Gupta, Sashi K.;Ferreira, Daneel
通讯作者：
Ferreira, Daneel
DOI：
10.1016/s1383-5718(02)00211-5
发表时间：
2002-11-26
影响因子：
1.9
作者：
Matsuoka, A;Takeshita, K;Miyata, N
通讯作者：
Miyata, N
影响因子：
6.1
作者：
Sobolev, VS;Deyrup, ST;Gloer, JB
通讯作者：
Gloer, JB