Association of HER-2 copy number and HER-2/CEP-17 ratio with neoadjuvant taxane-containing chemotherapy sensitivity in locally advanced breast cancer.
Association of HER-2 copy number and HER-2/CEP-17 ratio with neoadjuvant taxane-containing chemotherapy sensitivity in locally advanced breast cancer.
复制标题
HER-2 拷贝数和 HER-2/CEP-17 比率与局部晚期乳腺癌新辅助含紫杉烷化疗敏感性的关联。
DOI：
10.1634/theoncologist.2011-0381
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发表时间：
2012-06
期刊：
影响因子：
5.8
通讯作者：
Shao, Zhi-Ming
中科院分区：
文献类型：
--
作者：
Yu, Ke-Da;Liu, Guang-Yu;Zhou, Xiao-Yan;Zhou, Ying;Wu, Jiong;Chen, Can-Ming;Shen, Zhen-Zhou;Shao, Zhi-Ming
PURPOSE
Aneusomy 17 causes inconsistency in fluorescence in situ hybridization (FISH)-based human epidermal growth factor receptor (HER)-2 status assessment using different algorithms (copy number or the HER-2/centromere enumerator probe 17 [CEP-17] ratio). We investigated the effects of FISH-based HER-2 status assessment and aneusomy 17 on responsiveness to neoadjuvant chemotherapy (NAC).
PATIENTS AND METHODS
This prospective study recruited 152 patients with locally advanced breast cancer who underwent four-cycle weekly paclitaxel plus carboplatin without trastuzumab.
RESULTS
The pathologic complete remission (pCR) rate in the breast and axilla was 24.3% (95% confidence interval [CI], 17.7%-32.0%). Although HER-2 status, assessed by either HER-2/CEP-17 ratio-based FISH or copy number-based FISH, was a predictor of NAC sensitivity, ratio-assessed HER-2 status had a poorer performance in determining patients' responsiveness to NAC (p = .029). Patients who were not HER-2 amplified when assessed using the HER-2/CEP-17 ratio but were HER-2 amplified when assessed using copy number (~5%) were eventually proven to be responsive to NAC, with a pCR rate of 57% (95% CI, 18.4%-90.1%). In contrast, patients who were HER-2 amplified when assessed by the ratio but not HER-2 amplified when assessed using copy number (~3%) were completely irresponsive. Higher HER-2 copy numbers represented increasing chances of a pCR (adjusted odds ratio, 3.09; 95% CI, 1.35-7.08), with an apparent gene-dose effect (p for trend < .001).
CONCLUSION
It is likely that HER-2 copy number but not the HER-2/CEP-17 ratio determines NAC sensitivity. Additional studies to validate our findings are warranted.
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DOI：
10.1186/bcr996
发表时间：
2005
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Salido M;Tusquets I;Corominas JM;Suarez M;Espinet B;Corzo C;Bellet M;Fabregat X;Serrano S;Solé F
通讯作者：
Solé F
影响因子：
4.6
作者：
M. E. Hammond;Daniel F. Hayes;M. Dowsett;D. C. Allred;K. Hagerty;S. Badve;P. Fitzgibbons;G. Francis
通讯作者：
M. E. Hammond;Daniel F. Hayes;M. Dowsett;D. C. Allred;K. Hagerty;S. Badve;P. Fitzgibbons;G. Francis
影响因子：
10.3
作者：
Gennari, Alessandra;Sormani, Maria Pia;Bruzzi, Paolo
通讯作者：
Bruzzi, Paolo
影响因子：
4.6
作者：
R. Nagle;Tubbs Rr;P. Roche;E. Hsi;M. Linden;A. Ormsby;N. Pettigrew;R. Rickert;J. Said;I. Bayer-Garner;L. Cooley;A. Brothman;D. Persons;G. Vance;J. Mascarello;K. Rao;M. Herrmann;G. Dewald;Jonathan P. Park
通讯作者：
R. Nagle;Tubbs Rr;P. Roche;E. Hsi;M. Linden;A. Ormsby;N. Pettigrew;R. Rickert;J. Said;I. Bayer-Garner;L. Cooley;A. Brothman;D. Persons;G. Vance;J. Mascarello;K. Rao;M. Herrmann;G. Dewald;Jonathan P. Park
影响因子：
45.3
作者：
Vanden Bempt, Isabelle;Van Loo, Peter;De Wolf-Peeters, Christiane
通讯作者：
De Wolf-Peeters, Christiane